Novel locus including FGF21 is associated with dietary macronutrient intake

Audrey Y. Chu; Tsegaselassie Workalemahu; Nina P. Paynter; Lynda M. Rose; Franco Giulianini; Toshiko Tanaka; Julius S. Ngwa; Qibin Qi; Gary C. Curhan; Eric B. Rimm; David J. Hunter; Louis R. Pasquale; Paul M. Ridker; Frank B. Hu; Daniel I. Chasman; Lu Qi

doi:10.1093/hmg/ddt032

Novel locus including FGF21 is associated with dietary macronutrient intake

Audrey Y. Chu, Tsegaselassie Workalemahu, Nina P. Paynter, Lynda M. Rose, Franco Giulianini, Toshiko Tanaka, Julius S. Ngwa, Qibin Qi, Gary C. Curhan, Eric B. Rimm, David J. Hunter, Louis R. Pasquale, Paul M. Ridker, Frank B. Hu, Daniel I. Chasman, Lu Qi

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10^-5) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (P_joint = 7.9 × 10^-9). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.

Original language	English (US)
Article number	ddt032
Pages (from-to)	1895-1902
Number of pages	8
Journal	Human molecular genetics
Volume	22
Issue number	9
DOIs	https://doi.org/10.1093/hmg/ddt032
State	Published - May 2013
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/hmg/ddt032

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Chu, A. Y., Workalemahu, T., Paynter, N. P., Rose, L. M., Giulianini, F., Tanaka, T., Ngwa, J. S., Qi, Q., Curhan, G. C., Rimm, E. B., Hunter, D. J., Pasquale, L. R., Ridker, P. M., Hu, F. B., Chasman, D. I., & Qi, L. (2013). Novel locus including FGF21 is associated with dietary macronutrient intake. Human molecular genetics, 22(9), 1895-1902. [ddt032]. https://doi.org/10.1093/hmg/ddt032

@article{378ac777bd9040c79dbd2de9686dae44,

title = "Novel locus including FGF21 is associated with dietary macronutrient intake",

abstract = "Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10-5) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (Pjoint = 7.9 × 10-9). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.",

author = "Chu, {Audrey Y.} and Tsegaselassie Workalemahu and Paynter, {Nina P.} and Rose, {Lynda M.} and Franco Giulianini and Toshiko Tanaka and Ngwa, {Julius S.} and Qibin Qi and Curhan, {Gary C.} and Rimm, {Eric B.} and Hunter, {David J.} and Pasquale, {Louis R.} and Ridker, {Paul M.} and Hu, {Frank B.} and Chasman, {Daniel I.} and Lu Qi",

note = "Funding Information: The HPFS and NHS were supported by grants DK091718, HL71981, HL073168, CA87969, CA49449, HL34594, HL088521, U01HG004399, DK080140, DK58845 and DK46200 from the National Institutes of Health. The WGHS is supported by HL043851, HL080467 and CA058988 from the National Institutes of Health with collaborative scientific support and funding for genotyping provided by Amgen. L.Q. is a recipient of the American Heart Association Scientist Development Award (0730094N).",

year = "2013",

month = may,

doi = "10.1093/hmg/ddt032",

language = "English (US)",

volume = "22",

pages = "1895--1902",

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T1 - Novel locus including FGF21 is associated with dietary macronutrient intake

AU - Chu, Audrey Y.

AU - Workalemahu, Tsegaselassie

AU - Paynter, Nina P.

AU - Rose, Lynda M.

AU - Giulianini, Franco

AU - Tanaka, Toshiko

AU - Ngwa, Julius S.

AU - Qi, Qibin

AU - Curhan, Gary C.

AU - Rimm, Eric B.

AU - Hunter, David J.

AU - Pasquale, Louis R.

AU - Ridker, Paul M.

AU - Hu, Frank B.

AU - Chasman, Daniel I.

AU - Qi, Lu

N1 - Funding Information: The HPFS and NHS were supported by grants DK091718, HL71981, HL073168, CA87969, CA49449, HL34594, HL088521, U01HG004399, DK080140, DK58845 and DK46200 from the National Institutes of Health. The WGHS is supported by HL043851, HL080467 and CA058988 from the National Institutes of Health with collaborative scientific support and funding for genotyping provided by Amgen. L.Q. is a recipient of the American Heart Association Scientist Development Award (0730094N).

PY - 2013/5

Y1 - 2013/5

N2 - Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10-5) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (Pjoint = 7.9 × 10-9). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.

AB - Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10-5) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (Pjoint = 7.9 × 10-9). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.

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SN - 0964-6906

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JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 9

M1 - ddt032

ER -

Novel locus including FGF21 is associated with dietary macronutrient intake

Abstract

ASJC Scopus subject areas

UN SDGs

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