Novel locus including FGF21 is associated with dietary macronutrient intake

Audrey Y. Chu, Tsegaselassie Workalemahu, Nina P. Paynter, Lynda M. Rose, Franco Giulianini, Toshiko Tanaka, Julius S. Ngwa, Qibin Qi, Gary C. Curhan, Eric B. Rimm, David J. Hunter, Louis R. Pasquale, Paul M. Ridker, Frank B. Hu, Daniel I. Chasman, Lu Qi

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family studies have reported a moderate contribution of genetics to variation in macronutrient intake. In a genome-wide meta-analysis of a population-based discovery cohort (n = 33 533), rs838133 in FGF21 (19q13.33), rs197273 near TRAF family member-associated NF-kappa-B activator (TANK) (2p24.2), and rs10163409 in FTO (16q12.2) were among the top associations (P < 10-5) for percentage of total caloric intake from protein and carbohydrate. rs838133 was replicated in silico in an independent sample from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) Nutrition Working Group (n = 38 360) and attained genome-wide significance in combined analysis (Pjoint = 7.9 × 10-9). A cytokine involved in cellular metabolism, FGF21 is a potential susceptibility gene for obesity and type 2 diabetes. Our results highlight the potential of genetic variation for determining dietary macronutrient intake.

Original languageEnglish (US)
Article numberddt032
Pages (from-to)1895-1902
Number of pages8
JournalHuman Molecular Genetics
Volume22
Issue number9
DOIs
StatePublished - May 2013
Externally publishedYes

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Obesity
Carbohydrates
Genome
NF-kappa B
Energy Intake
Computer Simulation
Type 2 Diabetes Mellitus
Meta-Analysis
Epidemiology
Proteins
Fats
Cytokines
Research
Population
Genes
fibroblast growth factor 21

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Cite this

Chu, A. Y., Workalemahu, T., Paynter, N. P., Rose, L. M., Giulianini, F., Tanaka, T., ... Qi, L. (2013). Novel locus including FGF21 is associated with dietary macronutrient intake. Human Molecular Genetics, 22(9), 1895-1902. [ddt032]. https://doi.org/10.1093/hmg/ddt032

Novel locus including FGF21 is associated with dietary macronutrient intake. / Chu, Audrey Y.; Workalemahu, Tsegaselassie; Paynter, Nina P.; Rose, Lynda M.; Giulianini, Franco; Tanaka, Toshiko; Ngwa, Julius S.; Qi, Qibin; Curhan, Gary C.; Rimm, Eric B.; Hunter, David J.; Pasquale, Louis R.; Ridker, Paul M.; Hu, Frank B.; Chasman, Daniel I.; Qi, Lu.

In: Human Molecular Genetics, Vol. 22, No. 9, ddt032, 05.2013, p. 1895-1902.

Research output: Contribution to journalArticle

Chu, AY, Workalemahu, T, Paynter, NP, Rose, LM, Giulianini, F, Tanaka, T, Ngwa, JS, Qi, Q, Curhan, GC, Rimm, EB, Hunter, DJ, Pasquale, LR, Ridker, PM, Hu, FB, Chasman, DI & Qi, L 2013, 'Novel locus including FGF21 is associated with dietary macronutrient intake', Human Molecular Genetics, vol. 22, no. 9, ddt032, pp. 1895-1902. https://doi.org/10.1093/hmg/ddt032
Chu AY, Workalemahu T, Paynter NP, Rose LM, Giulianini F, Tanaka T et al. Novel locus including FGF21 is associated with dietary macronutrient intake. Human Molecular Genetics. 2013 May;22(9):1895-1902. ddt032. https://doi.org/10.1093/hmg/ddt032
Chu, Audrey Y. ; Workalemahu, Tsegaselassie ; Paynter, Nina P. ; Rose, Lynda M. ; Giulianini, Franco ; Tanaka, Toshiko ; Ngwa, Julius S. ; Qi, Qibin ; Curhan, Gary C. ; Rimm, Eric B. ; Hunter, David J. ; Pasquale, Louis R. ; Ridker, Paul M. ; Hu, Frank B. ; Chasman, Daniel I. ; Qi, Lu. / Novel locus including FGF21 is associated with dietary macronutrient intake. In: Human Molecular Genetics. 2013 ; Vol. 22, No. 9. pp. 1895-1902.
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