Novel delivery strategies for glioblastoma

Jiangbing Zhou, Kofi Buaku Atsina, Benjamin T. Himes, Garth W. Strohbehn, W. Mark Saltzman

Research output: Contribution to journalReview articlepeer-review

94 Scopus citations

Abstract

Brain tumors-particularly glioblastoma multiforme-pose an important public health problem in the United States. Despite surgical and medical advances, the prognosis for patients with malignant gliomas remains grim: current therapy is insufficient with nearly universal recurrence. A major reason for this failure is the difficulty of delivering therapeutic agents to the brain: better delivery approaches are needed to improve treatment. In this article, we summarize recent progress in drug delivery to the brain, with an emphasis on convection-enhanced delivery of nanocarriers. We examine the potential of new delivery methods to permit novel drug- and gene-based therapies that target brain cancer stem cells and discuss the use of nanomaterials for imaging of tumors and drug delivery.

Original languageEnglish (US)
Pages (from-to)89-99
Number of pages11
JournalCancer Journal
Volume18
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • brain cancer stem cells
  • convection-based delivery
  • Drug delivery
  • gene therapy
  • nanocarriers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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