Novel biomarkers of hyperlipidemic acute pancreatitis: Metabolomic identification

Yan Zhao, Wei Jia, Mingming Su, Yunping Qiu, Xingpeng Wang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Recognition of hypertriglyceridemia is critical for the diagnosis of hyperlipidemic pancreatitis (HLP) and the selection and evaluation of therapy. Objective: Investigate metabolic profiling technologies for identifying novel biomarkers and pathways activated in HLP. Methods: Blood and urine samples were obtained from 24 patients and 39 healthy people. A gas chromatography and mass spectrometry was employed to study the metabolic profile in HLP and healthy groups. Functional pathway trend analysis using multivariate statistical analysis was performed. Results: HLP patients could be precisely distinguished from the healthy controls. In the patient, levels of aconitate, citrate, hippurate, p-hydroxyphenylacetate and p-hydroxyphenylpopionic acid were decreased, while levels of tryptophan, tyrosine, tyramine,16-hexadecanoic acid, and 18-octadecanoic acid were increased. The change of energy metabolism-related mechanisms, fatty acid metabolism, gut microbiota metabolism, and metabolism of tyrosine could be used to distinguish HLP patients. Conclusions: Novel biomarkers could be identified by application of metabolomics. Metabolic profiling was useful for studies of pathogenesis of HLP.

Original languageEnglish (US)
Pages (from-to)765-769
Number of pages5
JournalAsian Biomedicine
Volume6
Issue number5
DOIs
StatePublished - Oct 1 2012

Keywords

  • Blood
  • Hyperlipidemic pancreatitis
  • Metabolism
  • Urine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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