Novel agents for the treatment of pancreatic adenocarcinoma

Haiying Cheng, Eirini Merika, Kostas N. Syrigos, Muhammad Wasif Saif

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

There are urgent needs to develop novel and more effective regimens to improve outcomes of pancreatic cancer given its dismal prognosis and limited treatment options. Several phase I clinical trials involving novel agents were recently presented at the 2011 American Society of Clinical Oncology (ASCO) Annual Meeting. It appears that hedgehog inhibition with IPI-926 was welltolerated and might be effective in treating pancreatic cancer when combined with gemcitabine. The survival benefits will be tested in the following randomized phase II trial. The new combination of gemcitabine and blockade of checkpoint kinases with AZD7762 showed an acceptable safety profile. Furthermore, inhibition of PI3K by BAY80-6946 was well tolerated with PET-CT suggesting reduction in FDG uptake in some pancreatic cancer. The benefits of above novel agents/regimens need to be further tested in phase II trials.

Original languageEnglish (US)
Pages (from-to)334-338
Number of pages5
JournalJournal of the Pancreas
Volume12
Issue number4
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Adenocarcinoma
  • Checkpoint kinase 1
  • Checkpoint kinase 2
  • Clinical Trials
  • Hedgehog Proteins
  • Pancreatic Neoplasms
  • Phase I as Topic /adverse effects
  • Protein Kinases
  • Protein-Serine-Threonine Kinases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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