Norovirus disease among older adults

Helen Tsai, Philip Yune, Mana Rao

Research output: Contribution to journalReview articlepeer-review

Abstract

Norovirus, a leading cause of gastroenteritis outbreaks worldwide, results in substantial direct and indirect healthcare costs. Adults older than 65 years of age bear a significant proportion of the disease burden, and the disease course in this population is often more severe and protracted. In this narrative review, we discuss the epidemiology of norovirus infection, mechanisms of pathogenesis, and transmission pertinent to outbreaks along with infection prevention and control efforts. We also describe the clinical manifestations of norovirus disease with a focus on individuals older than 65 years of age, diagnosis and available treatment options, and the challenges and progress within vaccine development.

Original languageEnglish (US)
JournalTherapeutic Advances in Infectious Disease
Volume9
DOIs
StatePublished - 2022

Keywords

  • norovirus
  • older adults

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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