Normal echocardiographic measurements in uncomplicated pregnancy, a single center experience

Geoffrey J. Tso, Jennifer M. Lee, Nada M. Shaban, George K. Lui, Heather A. Trivedi, Martin N. Cohen, Peter S. Bernstein, Cynthia C. Taub

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Cardiovascular changes of pregnancy are well-known; however, parameters for accurately assessing these changes have not been refined as measurement tools have advanced. We sought to examine the range of echocardiographic parameters during normal pregnancy using current echocardiographic imaging modalities. Methods: We performed a retrospective analysis of normal echocardiograms in 121 women (97 pregnant, 24 non-pregnant) without evidence of cardiovascular disease. Linear, area, and Doppler flow measurements were made of commonly reviewed cardiac structures. Height-indexed measurements were compared between pregnant women and controls and between trimesters of pregnancy. Results: Compared to non-pregnant patients, all four cardiac chambers showed significant enlargement in the pregnant patients. The left atrium was the first chamber to enlarge. LV mass also increased in the third trimester (134.5 ± 31 vs. 112.3 ± 28.2 g, P < 0.01), with preservation of LV mass to volume ratio. LV ejection fraction was significantly larger (68% vs. 63%, P < 0.036) in the second trimester patients, but decreased into the third trimester (64.1% ± 6.8%, P < 0.006). When pulmonary artery systolic pressure (PASP) was calculated from the pulmonary artery acceleration time, observed pressures were significantly greater in the third trimester than second trimester (40.1 ± 10.3 vs. 45.5 ± 10.1 mmHg, P = 0.029). PASP calculated conventionally from tricuspid regurgitation gradient did not show similar significance. There was no significant change in diastolic parameters throughout pregnancy. Conclusions: This study provides data on echocardiographic parameters during normal pregnancy and is one of the largest sample sizes in the literature. The results will contribute to the current literature by helping to distinguish between normal and abnormal echocardiograms during pregnancy.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalJournal of Cardiovascular Disease Research
Volume5
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Third Pregnancy Trimester
Pregnancy
Pulmonary Artery
Second Pregnancy Trimester
Pregnant Women
Pregnancy Trimesters
Blood Pressure
Tricuspid Valve Insufficiency
Heart Atria
Sample Size
Cardiovascular Diseases
Pressure

Keywords

  • Chamber quantifications
  • Echocardiography
  • Pregnancy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Normal echocardiographic measurements in uncomplicated pregnancy, a single center experience. / Tso, Geoffrey J.; Lee, Jennifer M.; Shaban, Nada M.; Lui, George K.; Trivedi, Heather A.; Cohen, Martin N.; Bernstein, Peter S.; Taub, Cynthia C.

In: Journal of Cardiovascular Disease Research, Vol. 5, No. 2, 2014, p. 3-8.

Research output: Contribution to journalArticle

Tso, Geoffrey J. ; Lee, Jennifer M. ; Shaban, Nada M. ; Lui, George K. ; Trivedi, Heather A. ; Cohen, Martin N. ; Bernstein, Peter S. ; Taub, Cynthia C. / Normal echocardiographic measurements in uncomplicated pregnancy, a single center experience. In: Journal of Cardiovascular Disease Research. 2014 ; Vol. 5, No. 2. pp. 3-8.
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abstract = "Background: Cardiovascular changes of pregnancy are well-known; however, parameters for accurately assessing these changes have not been refined as measurement tools have advanced. We sought to examine the range of echocardiographic parameters during normal pregnancy using current echocardiographic imaging modalities. Methods: We performed a retrospective analysis of normal echocardiograms in 121 women (97 pregnant, 24 non-pregnant) without evidence of cardiovascular disease. Linear, area, and Doppler flow measurements were made of commonly reviewed cardiac structures. Height-indexed measurements were compared between pregnant women and controls and between trimesters of pregnancy. Results: Compared to non-pregnant patients, all four cardiac chambers showed significant enlargement in the pregnant patients. The left atrium was the first chamber to enlarge. LV mass also increased in the third trimester (134.5 ± 31 vs. 112.3 ± 28.2 g, P < 0.01), with preservation of LV mass to volume ratio. LV ejection fraction was significantly larger (68{\%} vs. 63{\%}, P < 0.036) in the second trimester patients, but decreased into the third trimester (64.1{\%} ± 6.8{\%}, P < 0.006). When pulmonary artery systolic pressure (PASP) was calculated from the pulmonary artery acceleration time, observed pressures were significantly greater in the third trimester than second trimester (40.1 ± 10.3 vs. 45.5 ± 10.1 mmHg, P = 0.029). PASP calculated conventionally from tricuspid regurgitation gradient did not show similar significance. There was no significant change in diastolic parameters throughout pregnancy. Conclusions: This study provides data on echocardiographic parameters during normal pregnancy and is one of the largest sample sizes in the literature. The results will contribute to the current literature by helping to distinguish between normal and abnormal echocardiograms during pregnancy.",
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AB - Background: Cardiovascular changes of pregnancy are well-known; however, parameters for accurately assessing these changes have not been refined as measurement tools have advanced. We sought to examine the range of echocardiographic parameters during normal pregnancy using current echocardiographic imaging modalities. Methods: We performed a retrospective analysis of normal echocardiograms in 121 women (97 pregnant, 24 non-pregnant) without evidence of cardiovascular disease. Linear, area, and Doppler flow measurements were made of commonly reviewed cardiac structures. Height-indexed measurements were compared between pregnant women and controls and between trimesters of pregnancy. Results: Compared to non-pregnant patients, all four cardiac chambers showed significant enlargement in the pregnant patients. The left atrium was the first chamber to enlarge. LV mass also increased in the third trimester (134.5 ± 31 vs. 112.3 ± 28.2 g, P < 0.01), with preservation of LV mass to volume ratio. LV ejection fraction was significantly larger (68% vs. 63%, P < 0.036) in the second trimester patients, but decreased into the third trimester (64.1% ± 6.8%, P < 0.006). When pulmonary artery systolic pressure (PASP) was calculated from the pulmonary artery acceleration time, observed pressures were significantly greater in the third trimester than second trimester (40.1 ± 10.3 vs. 45.5 ± 10.1 mmHg, P = 0.029). PASP calculated conventionally from tricuspid regurgitation gradient did not show similar significance. There was no significant change in diastolic parameters throughout pregnancy. Conclusions: This study provides data on echocardiographic parameters during normal pregnancy and is one of the largest sample sizes in the literature. The results will contribute to the current literature by helping to distinguish between normal and abnormal echocardiograms during pregnancy.

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