Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation

Ulrich K. Schubart, Jinghua Yu, Jose A. Amat, Zhi Qin Wang, Michael K. Hoffmann, Winfried Edelmann

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Metablastin, also called P19, stathmin, prosolin, Lap18, and oncoprotein 18, is a highly conserved cytosolic protein that undergoes extracellular factor- and cell cycle-regulated serine phosphorylation and developmentally regulated expression in mammals. It has been implicated in a variety of cellular functions including growth and differentiation, and recent evidence suggests an involvement in cell cycle control. To explore its potential role in mammalian development, we have disrupted the gene encoding metablastin by gene targeting in mice. The metablastin null mutants have no overt phenotype regarding development, growth rate, behavior, T cell maturation, or fertility and do not exhibit an increased predisposition to tumors. SCG10, a protein closely related in structure to metablastin, shows no compensatory up- regulation in metablastin(-/-) mice. Although the data suggest that metablastin is not essential for mammalian development, the knockout mice should prove valuable in exploring the role of this protein in cell cycle regulation.

Original languageEnglish (US)
Pages (from-to)14062-14066
Number of pages5
JournalJournal of Biological Chemistry
Volume271
Issue number24
DOIs
StatePublished - 1996

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Stathmin
Phosphoproteins
Cell Cycle
Cells
Cell Cycle Proteins
Phosphorylation
Proteins
Gene encoding
Mammals
T-cells
Gene Targeting
Cell Cycle Checkpoints
Growth and Development
Knockout Mice
Serine
Fertility
Tumors
Up-Regulation
Genes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation. / Schubart, Ulrich K.; Yu, Jinghua; Amat, Jose A.; Wang, Zhi Qin; Hoffmann, Michael K.; Edelmann, Winfried.

In: Journal of Biological Chemistry, Vol. 271, No. 24, 1996, p. 14062-14066.

Research output: Contribution to journalArticle

Schubart, Ulrich K. ; Yu, Jinghua ; Amat, Jose A. ; Wang, Zhi Qin ; Hoffmann, Michael K. ; Edelmann, Winfried. / Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation. In: Journal of Biological Chemistry. 1996 ; Vol. 271, No. 24. pp. 14062-14066.
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