Nonesterified fatty acids and risk of sudden cardiac death in older adults

Luc Djoussé, Mary L. Biggs, Joachim H. Ix, Jorge Kizer, Rozenn N. Lemaitre, Nona Sotoodehnia, Susan J. Zieman, Dariush Mozaffarian, Russell P. Tracy, Kenneth J. Mukamal, David S. Siscovick

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background-Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death. Methods and Results-Using a prospective design, we studied 4657 older men and women (mean age, 75 years) from the Cardiovascular Health Study (1992-2006) to evaluate the association between plasma NEFA and the risk of sudden cardiac death in older adults. Plasma concentrations of NEFA were measured using established enzymatic methods, and sudden death was adjudicated using medical records, death certificates, proxy interview, and autopsy reports. We used Cox proportional hazard models to estimate multivariable-adjusted relative risks. During a median follow-up of 10.0 years, 221 new cases of sudden cardiac death occurred. In a multivariable model adjusting for age, sex, race, clinic site, alcohol intake, smoking, prevalent coronary heart disease and heart failure, and self-reported health status, relative risks (95% confidence interval) for sudden cardiac death were 1.0 (ref), 1.15 (0.81-1.64), 1.06 (0.72-1.55), and 0.91 (0.60 -1.38) across consecutive quartiles of NEFA concentration. In secondary analyses restricted to the first 5 years of follow-up, we also did not observe a statistically significant association between plasma NEFA and sudden cardiac death. Conclusions-Our data do not provide evidence for an association between plasma NEFA measured late in life and the risk of sudden cardiac death in older adults.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalCirculation: Arrhythmia and Electrophysiology
Volume5
Issue number2
DOIs
StatePublished - Apr 2012
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Nonesterified Fatty Acids
Coronary Disease
Death Certificates
Proxy
Sudden Death
Proportional Hazards Models
Health Status
Medical Records
Autopsy
Heart Failure
Smoking
Alcohols
Confidence Intervals
Interviews
Health

Keywords

  • Epidemiology
  • Fatty acids
  • Risk factors
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Djoussé, L., Biggs, M. L., Ix, J. H., Kizer, J., Lemaitre, R. N., Sotoodehnia, N., ... Siscovick, D. S. (2012). Nonesterified fatty acids and risk of sudden cardiac death in older adults. Circulation: Arrhythmia and Electrophysiology, 5(2), 273-278. https://doi.org/10.1161/CIRCEP.111.967661

Nonesterified fatty acids and risk of sudden cardiac death in older adults. / Djoussé, Luc; Biggs, Mary L.; Ix, Joachim H.; Kizer, Jorge; Lemaitre, Rozenn N.; Sotoodehnia, Nona; Zieman, Susan J.; Mozaffarian, Dariush; Tracy, Russell P.; Mukamal, Kenneth J.; Siscovick, David S.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 5, No. 2, 04.2012, p. 273-278.

Research output: Contribution to journalArticle

Djoussé, L, Biggs, ML, Ix, JH, Kizer, J, Lemaitre, RN, Sotoodehnia, N, Zieman, SJ, Mozaffarian, D, Tracy, RP, Mukamal, KJ & Siscovick, DS 2012, 'Nonesterified fatty acids and risk of sudden cardiac death in older adults', Circulation: Arrhythmia and Electrophysiology, vol. 5, no. 2, pp. 273-278. https://doi.org/10.1161/CIRCEP.111.967661
Djoussé, Luc ; Biggs, Mary L. ; Ix, Joachim H. ; Kizer, Jorge ; Lemaitre, Rozenn N. ; Sotoodehnia, Nona ; Zieman, Susan J. ; Mozaffarian, Dariush ; Tracy, Russell P. ; Mukamal, Kenneth J. ; Siscovick, David S. / Nonesterified fatty acids and risk of sudden cardiac death in older adults. In: Circulation: Arrhythmia and Electrophysiology. 2012 ; Vol. 5, No. 2. pp. 273-278.
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abstract = "Background-Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death. Methods and Results-Using a prospective design, we studied 4657 older men and women (mean age, 75 years) from the Cardiovascular Health Study (1992-2006) to evaluate the association between plasma NEFA and the risk of sudden cardiac death in older adults. Plasma concentrations of NEFA were measured using established enzymatic methods, and sudden death was adjudicated using medical records, death certificates, proxy interview, and autopsy reports. We used Cox proportional hazard models to estimate multivariable-adjusted relative risks. During a median follow-up of 10.0 years, 221 new cases of sudden cardiac death occurred. In a multivariable model adjusting for age, sex, race, clinic site, alcohol intake, smoking, prevalent coronary heart disease and heart failure, and self-reported health status, relative risks (95{\%} confidence interval) for sudden cardiac death were 1.0 (ref), 1.15 (0.81-1.64), 1.06 (0.72-1.55), and 0.91 (0.60 -1.38) across consecutive quartiles of NEFA concentration. In secondary analyses restricted to the first 5 years of follow-up, we also did not observe a statistically significant association between plasma NEFA and sudden cardiac death. Conclusions-Our data do not provide evidence for an association between plasma NEFA measured late in life and the risk of sudden cardiac death in older adults.",
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AU - Sotoodehnia, Nona

AU - Zieman, Susan J.

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AB - Background-Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death. Methods and Results-Using a prospective design, we studied 4657 older men and women (mean age, 75 years) from the Cardiovascular Health Study (1992-2006) to evaluate the association between plasma NEFA and the risk of sudden cardiac death in older adults. Plasma concentrations of NEFA were measured using established enzymatic methods, and sudden death was adjudicated using medical records, death certificates, proxy interview, and autopsy reports. We used Cox proportional hazard models to estimate multivariable-adjusted relative risks. During a median follow-up of 10.0 years, 221 new cases of sudden cardiac death occurred. In a multivariable model adjusting for age, sex, race, clinic site, alcohol intake, smoking, prevalent coronary heart disease and heart failure, and self-reported health status, relative risks (95% confidence interval) for sudden cardiac death were 1.0 (ref), 1.15 (0.81-1.64), 1.06 (0.72-1.55), and 0.91 (0.60 -1.38) across consecutive quartiles of NEFA concentration. In secondary analyses restricted to the first 5 years of follow-up, we also did not observe a statistically significant association between plasma NEFA and sudden cardiac death. Conclusions-Our data do not provide evidence for an association between plasma NEFA measured late in life and the risk of sudden cardiac death in older adults.

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