Nonenzymatic glycosylation of macromolecules: Prospects of pharmacologic modulation

M. Brownlee

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Diabetes increases the risk of developing atherosclerotic arterial disease significantly. Although elevated glycohemoglobin was shown to be an independent risk factor in older women in the Framingham Heart Study, the relationship between hyperglycemia and macrovascular disease is complicated by the many other factors that influence atherogenesis in nondiabetic people. Studies in vitro suggest that chronic hyperglycemia may accelerate the atherogenic process through excessive glycation of various components of the arterial wall. These data are reviewed critically, and the biochemistry and pharmacological potential of the glycation-inhibitor aminoguanidine is discussed.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalDiabetes
Volume41
Issue numberSUPPL. 2
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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