Noncoding RNAs in long-term memory formation

Tim R. Mercer, Marcel E. Dinger, Jean Mariani, Kenneth S. Kosik, Mark F. Mehler, John S. Mattick

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Current research exploring the molecular basis of memory focuses mainly on proteins despite recent genomic studies reporting the abundant transcription of non-protein-coding RNA (ncRNA). Although ncRNAs are involved in a diverse range of biological processes, they are particularly prevalent within the nervous system, where they contribute towards the complexity and function of the mammalian brain. In this review, we apply recent advances in ncRNA biology to predict a critical role for ncRNAs in the molecular mechanisms underlying memory formation and maintenance. We describe the role of ncRNAs in regulating the translation, stability, and editing of mRNA populations in response to synaptic activity during memory formation and the role of ncRNAs in the epigenetic and transcriptional programs that underlie long-term memory storage. We also consider ncRNAs acting as an additional avenue of communication between neurons by their intercellular trafficking. Taken together, the emerging evidence suggests a central role for ncRNAs in memory formation and provokes novel research directions in this field.

Original languageEnglish (US)
Pages (from-to)434-445
Number of pages12
JournalNeuroscientist
Volume14
Issue number5
DOIs
StatePublished - Oct 2008

Fingerprint

Untranslated RNA
Long-Term Memory
Biological Phenomena
RNA Stability
Research
Epigenomics
Nervous System
Communication
Maintenance
Neurons
Brain
Population
Proteins

Keywords

  • Intercellular signaling
  • Long-term potentiation
  • microRNAs
  • Neuron
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Mercer, T. R., Dinger, M. E., Mariani, J., Kosik, K. S., Mehler, M. F., & Mattick, J. S. (2008). Noncoding RNAs in long-term memory formation. Neuroscientist, 14(5), 434-445. https://doi.org/10.1177/1073858408319187

Noncoding RNAs in long-term memory formation. / Mercer, Tim R.; Dinger, Marcel E.; Mariani, Jean; Kosik, Kenneth S.; Mehler, Mark F.; Mattick, John S.

In: Neuroscientist, Vol. 14, No. 5, 10.2008, p. 434-445.

Research output: Contribution to journalArticle

Mercer, TR, Dinger, ME, Mariani, J, Kosik, KS, Mehler, MF & Mattick, JS 2008, 'Noncoding RNAs in long-term memory formation', Neuroscientist, vol. 14, no. 5, pp. 434-445. https://doi.org/10.1177/1073858408319187
Mercer TR, Dinger ME, Mariani J, Kosik KS, Mehler MF, Mattick JS. Noncoding RNAs in long-term memory formation. Neuroscientist. 2008 Oct;14(5):434-445. https://doi.org/10.1177/1073858408319187
Mercer, Tim R. ; Dinger, Marcel E. ; Mariani, Jean ; Kosik, Kenneth S. ; Mehler, Mark F. ; Mattick, John S. / Noncoding RNAs in long-term memory formation. In: Neuroscientist. 2008 ; Vol. 14, No. 5. pp. 434-445.
@article{11bd12e0d72c4083ac908c8184da89d3,
title = "Noncoding RNAs in long-term memory formation",
abstract = "Current research exploring the molecular basis of memory focuses mainly on proteins despite recent genomic studies reporting the abundant transcription of non-protein-coding RNA (ncRNA). Although ncRNAs are involved in a diverse range of biological processes, they are particularly prevalent within the nervous system, where they contribute towards the complexity and function of the mammalian brain. In this review, we apply recent advances in ncRNA biology to predict a critical role for ncRNAs in the molecular mechanisms underlying memory formation and maintenance. We describe the role of ncRNAs in regulating the translation, stability, and editing of mRNA populations in response to synaptic activity during memory formation and the role of ncRNAs in the epigenetic and transcriptional programs that underlie long-term memory storage. We also consider ncRNAs acting as an additional avenue of communication between neurons by their intercellular trafficking. Taken together, the emerging evidence suggests a central role for ncRNAs in memory formation and provokes novel research directions in this field.",
keywords = "Intercellular signaling, Long-term potentiation, microRNAs, Neuron, Synaptic plasticity",
author = "Mercer, {Tim R.} and Dinger, {Marcel E.} and Jean Mariani and Kosik, {Kenneth S.} and Mehler, {Mark F.} and Mattick, {John S.}",
year = "2008",
month = "10",
doi = "10.1177/1073858408319187",
language = "English (US)",
volume = "14",
pages = "434--445",
journal = "Neuroscientist",
issn = "1073-8584",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Noncoding RNAs in long-term memory formation

AU - Mercer, Tim R.

AU - Dinger, Marcel E.

AU - Mariani, Jean

AU - Kosik, Kenneth S.

AU - Mehler, Mark F.

AU - Mattick, John S.

PY - 2008/10

Y1 - 2008/10

N2 - Current research exploring the molecular basis of memory focuses mainly on proteins despite recent genomic studies reporting the abundant transcription of non-protein-coding RNA (ncRNA). Although ncRNAs are involved in a diverse range of biological processes, they are particularly prevalent within the nervous system, where they contribute towards the complexity and function of the mammalian brain. In this review, we apply recent advances in ncRNA biology to predict a critical role for ncRNAs in the molecular mechanisms underlying memory formation and maintenance. We describe the role of ncRNAs in regulating the translation, stability, and editing of mRNA populations in response to synaptic activity during memory formation and the role of ncRNAs in the epigenetic and transcriptional programs that underlie long-term memory storage. We also consider ncRNAs acting as an additional avenue of communication between neurons by their intercellular trafficking. Taken together, the emerging evidence suggests a central role for ncRNAs in memory formation and provokes novel research directions in this field.

AB - Current research exploring the molecular basis of memory focuses mainly on proteins despite recent genomic studies reporting the abundant transcription of non-protein-coding RNA (ncRNA). Although ncRNAs are involved in a diverse range of biological processes, they are particularly prevalent within the nervous system, where they contribute towards the complexity and function of the mammalian brain. In this review, we apply recent advances in ncRNA biology to predict a critical role for ncRNAs in the molecular mechanisms underlying memory formation and maintenance. We describe the role of ncRNAs in regulating the translation, stability, and editing of mRNA populations in response to synaptic activity during memory formation and the role of ncRNAs in the epigenetic and transcriptional programs that underlie long-term memory storage. We also consider ncRNAs acting as an additional avenue of communication between neurons by their intercellular trafficking. Taken together, the emerging evidence suggests a central role for ncRNAs in memory formation and provokes novel research directions in this field.

KW - Intercellular signaling

KW - Long-term potentiation

KW - microRNAs

KW - Neuron

KW - Synaptic plasticity

UR - http://www.scopus.com/inward/record.url?scp=52449130135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52449130135&partnerID=8YFLogxK

U2 - 10.1177/1073858408319187

DO - 10.1177/1073858408319187

M3 - Article

C2 - 18997122

AN - SCOPUS:52449130135

VL - 14

SP - 434

EP - 445

JO - Neuroscientist

JF - Neuroscientist

SN - 1073-8584

IS - 5

ER -