Nonalcoholic Fatty Liver Disease and Mean Platelet Volume: A Systemic Review and Meta-analysis

Shivank A. Madan, Febin John, Capecomorin S. Pitchumoni

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is linked to obesity, metabolic syndrome, and cardiovascular disease. Increased mean platelet volume (MPV), a marker of platelet activity, is associated with acute myocardial infarction, stroke, thrombosis, and increased mortality after myocardial infarction. The purpose of this study was to perform a meta-analysis to investigate the relationship between NAFLD and MPV. Methodology: A systematic search of MEDLINE (Ovid), PubMed, and CINAHL databases from 1950 to May 2014, complemented with manual review of references of published articles for studies comparing MPV in patients with and without NAFLD was done. Results were pooled using both fixed and random effects model. Results: Our analysis from pooling of data from 8 observational studies including 1428 subjects (NAFLD=842 and non-NAFLD=586) showed that MPV was significantly higher in patients with NAFLD than those without. The standardized mean difference in MPV between NAFLD and controls was 0.457 (95% confidence interval: 0.348-0.565, P 0.001) using fixed and 0.612 (95% confidence interval: 0.286-0.938, P 0.001) using random effects model. Conclusions: This study suggests that MPV is significantly higher in patients with NAFLD, indicating the presence of increased platelet activity in such patients. Future research is needed to investigate whether this increased MPV is associated with increased cardiovascular disease in patients with NAFLD.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalJournal of clinical gastroenterology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • mean platelet volume
  • MPV
  • NAFLD
  • Nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint

Dive into the research topics of 'Nonalcoholic Fatty Liver Disease and Mean Platelet Volume: A Systemic Review and Meta-analysis'. Together they form a unique fingerprint.

Cite this