Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

Seth T. Walk; Ruchika Jain; Itishree Trivedi; Sylvia Grossman; Duane W. Newton; Tennille Thelen; Yibai Hao; J. Glenn Songer; Glen P. Carter; Dena Lyras; Vincent B. Young; David M. Aronoff

doi:10.1016/j.anaerobe.2011.06.009

Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

Seth T. Walk, Ruchika Jain, Itishree Trivedi, Sylvia Grossman, Duane W. Newton, Tennille Thelen, Yibai Hao, J. Glenn Songer, Glen P. Carter, Dena Lyras, Vincent B. Young, David M. Aronoff

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.

Original language	English (US)
Pages (from-to)	252-256
Number of pages	5
Journal	Anaerobe
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.anaerobe.2011.06.009
State	Published - Oct 2011
Externally published	Yes

Keywords

Cholangitis
Clostridia
Cytotoxicity
Sepsis
Toxic shock syndrome

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.anaerobe.2011.06.009

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@article{e45be30b6cd846cba74a078bd9560513,

title = "Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia",

abstract = "Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.",

keywords = "Cholangitis, Clostridia, Cytotoxicity, Sepsis, Toxic shock syndrome",

author = "Walk, {Seth T.} and Ruchika Jain and Itishree Trivedi and Sylvia Grossman and Newton, {Duane W.} and Tennille Thelen and Yibai Hao and Songer, {J. Glenn} and Carter, {Glen P.} and Dena Lyras and Young, {Vincent B.} and Aronoff, {David M.}",

note = "Funding Information: This work was supported by National Institutes of Health grant HL078727 (D.M.A.) and UL1RR024986 (S.T.W.) from the National Center for Research Resources . The non-animal research was supported by a Doris Duke Charitable Foundation Clinical Scientist Development Award (D.M.A.).",

year = "2011",

month = oct,

doi = "10.1016/j.anaerobe.2011.06.009",

language = "English (US)",

volume = "17",

pages = "252--256",

journal = "Anaerobe",

issn = "1075-9964",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Non-toxigenic Clostridium sordellii

T2 - Clinical and microbiological features of a case of cholangitis-associated bacteremia

AU - Walk, Seth T.

AU - Jain, Ruchika

AU - Trivedi, Itishree

AU - Grossman, Sylvia

AU - Newton, Duane W.

AU - Thelen, Tennille

AU - Hao, Yibai

AU - Songer, J. Glenn

AU - Carter, Glen P.

AU - Lyras, Dena

AU - Young, Vincent B.

AU - Aronoff, David M.

N1 - Funding Information: This work was supported by National Institutes of Health grant HL078727 (D.M.A.) and UL1RR024986 (S.T.W.) from the National Center for Research Resources . The non-animal research was supported by a Doris Duke Charitable Foundation Clinical Scientist Development Award (D.M.A.).

PY - 2011/10

Y1 - 2011/10

N2 - Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.

AB - Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or the tcsH gene for TcsH. In addition, the strain was neither cytotoxic in vitro nor lethal in a murine sepsis model. These results provide additional correlative evidence that TcsL and TcsH increase the risk of mortality during C. sordellii infections.

KW - Cholangitis

KW - Clostridia

KW - Cytotoxicity

KW - Sepsis

KW - Toxic shock syndrome

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ER -

Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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