No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study

Shiwei Duan, Hua Yin, Wuyan Chen, Qinhe Xing, Qi Chen, Tingwei Guo, Jianjun Gao, Xiuxia Li, Rui Gao, Zhuangjun Liu, Niufan Gu, Guoyin Feng, Lin He

Research output: Contribution to journalArticle

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Abstract

Previous studies have demonstrated that polymorphisms in the putative promoter region of the human serotonin receptor 1B (HTR1B) gene affect gene expression [H.F. Sun, Y.T. Chang, C.S. Fann, C.J. Chang, Y.H. Chen, Y.P. Hsu, W.Y. Yu, A.T. Cheng, Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han, Biol. Psychiatry 51 (2002) 896-901; J. Duan, A.R. Sanders, J.E. Molen, L. Martinolich, B.J. Mowry, D.F. Levinson, R.R. Crowe, J.M. Silverman, P.V. Gejman, Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression, Mol. Psychiatry 8 (2003) 901-910]. And the silent mutation G861C allele has been reported to be associated with several psychiatric disorders. Thus, we performed a case-control association study (456 cases and 557 controls) of the five variants in HTR1B gene (T-261G, -182INS/DEL-181, A-161T, C129T and G861C) with schizophrenia. The results showed that neither the allelic distribution nor the major haplotype distribution (except for a rare haplotype) of five SNPs in patients was significantly different from that in controls. A further family-based association study (229 family trios) of G861C allele suggested that HTR1B was not a susceptible gene with schizophrenia in our sample. In conclusion, these data do not support the idea that HTR1B gene plays a major role in the etiopathogenesis of schizophrenia in Chinese Han population.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalNeuroscience Letters
Volume376
Issue number2
DOIs
StatePublished - Mar 11 2005
Externally publishedYes

Fingerprint

Receptor, Serotonin, 5-HT1B
Schizophrenia
Genes
Psychiatry
Haplotypes
Serotonin
Alleles
Gene Expression
5' Untranslated Regions
Solar System
Genetic Promoter Regions
Alcoholism
Single Nucleotide Polymorphism
Case-Control Studies
Population

Keywords

  • Association study
  • HTR1B
  • Polymorphisms
  • Schizophrenia
  • Serotonin receptor
  • TDT

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. / Duan, Shiwei; Yin, Hua; Chen, Wuyan; Xing, Qinhe; Chen, Qi; Guo, Tingwei; Gao, Jianjun; Li, Xiuxia; Gao, Rui; Liu, Zhuangjun; Gu, Niufan; Feng, Guoyin; He, Lin.

In: Neuroscience Letters, Vol. 376, No. 2, 11.03.2005, p. 93-97.

Research output: Contribution to journalArticle

Duan, S, Yin, H, Chen, W, Xing, Q, Chen, Q, Guo, T, Gao, J, Li, X, Gao, R, Liu, Z, Gu, N, Feng, G & He, L 2005, 'No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study', Neuroscience Letters, vol. 376, no. 2, pp. 93-97. https://doi.org/10.1016/j.neulet.2004.11.028
Duan, Shiwei ; Yin, Hua ; Chen, Wuyan ; Xing, Qinhe ; Chen, Qi ; Guo, Tingwei ; Gao, Jianjun ; Li, Xiuxia ; Gao, Rui ; Liu, Zhuangjun ; Gu, Niufan ; Feng, Guoyin ; He, Lin. / No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. In: Neuroscience Letters. 2005 ; Vol. 376, No. 2. pp. 93-97.
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AU - Duan, Shiwei

AU - Yin, Hua

AU - Chen, Wuyan

AU - Xing, Qinhe

AU - Chen, Qi

AU - Guo, Tingwei

AU - Gao, Jianjun

AU - Li, Xiuxia

AU - Gao, Rui

AU - Liu, Zhuangjun

AU - Gu, Niufan

AU - Feng, Guoyin

AU - He, Lin

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