No association between the promoter variants of tumor necrosis factor alpha (TNF-α) and schizophrenia in Chinese Han population

Shiwei Duan, Yifeng Xu, Wuyan Chen, Zhuangjun Liu, Tingwei Guo, Jianjun Gao, Li Bian, Yonglan Zhen, Xiuxia Li, Xiaoju Zhang, Yuxi Pan, Niufan Gu, Guoyin Feng, Lin He

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with activation of the immune system. Four studies have established an association of -308G/A polymorphism of tumor necrosis factor alpha (TNF-α), a cytokine involved in inflammatory processes, with schizophrenia [Mol. Psychiatry 6 (2001) 79; Mol. Psychiatry 8 (2003) 718; Schizophr. Res. 65 (2003) 19; Biol. Psychiatry 54 (2003) 1205]. In the present study, however, no significant positive association has been found between any individual SNP or haplotype constituted of the five promoter polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A and -238G/A) in the human TNF-α gene and schizophrenia (314 Chinese Han schizophrenic patients and 340 healthy control). A meta-analysis we did in this work, which is based on previous nine studies plus our own unpublished data including a total of 2399 schizophrenic patients (sporadic cases 2099, familial cases >505) and more than 3261 controls, failed to show significant difference of -308G/A distribution between patients and controls in both the whole sample and the pooled Asian sample. By contraries, the significant results in the pooled Caucasian sample imply an ethnic heterogeneity in -308G/A variation in the TNF-α gene in schizophrenia.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalNeuroscience Letters
Volume366
Issue number2
DOIs
StatePublished - Aug 12 2004
Externally publishedYes

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Schizophrenia
Tumor Necrosis Factor-alpha
Psychiatry
Population
Haplotypes
Genes
Single Nucleotide Polymorphism
Meta-Analysis
Immune System
Cytokines

Keywords

  • Association study
  • Polymorphisms
  • Promoter
  • Schizophrenia
  • TNF-α
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

No association between the promoter variants of tumor necrosis factor alpha (TNF-α) and schizophrenia in Chinese Han population. / Duan, Shiwei; Xu, Yifeng; Chen, Wuyan; Liu, Zhuangjun; Guo, Tingwei; Gao, Jianjun; Bian, Li; Zhen, Yonglan; Li, Xiuxia; Zhang, Xiaoju; Pan, Yuxi; Gu, Niufan; Feng, Guoyin; He, Lin.

In: Neuroscience Letters, Vol. 366, No. 2, 12.08.2004, p. 139-143.

Research output: Contribution to journalArticle

Duan, S, Xu, Y, Chen, W, Liu, Z, Guo, T, Gao, J, Bian, L, Zhen, Y, Li, X, Zhang, X, Pan, Y, Gu, N, Feng, G & He, L 2004, 'No association between the promoter variants of tumor necrosis factor alpha (TNF-α) and schizophrenia in Chinese Han population', Neuroscience Letters, vol. 366, no. 2, pp. 139-143. https://doi.org/10.1016/j.neulet.2004.05.039
Duan, Shiwei ; Xu, Yifeng ; Chen, Wuyan ; Liu, Zhuangjun ; Guo, Tingwei ; Gao, Jianjun ; Bian, Li ; Zhen, Yonglan ; Li, Xiuxia ; Zhang, Xiaoju ; Pan, Yuxi ; Gu, Niufan ; Feng, Guoyin ; He, Lin. / No association between the promoter variants of tumor necrosis factor alpha (TNF-α) and schizophrenia in Chinese Han population. In: Neuroscience Letters. 2004 ; Vol. 366, No. 2. pp. 139-143.
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AU - Xu, Yifeng

AU - Chen, Wuyan

AU - Liu, Zhuangjun

AU - Guo, Tingwei

AU - Gao, Jianjun

AU - Bian, Li

AU - Zhen, Yonglan

AU - Li, Xiuxia

AU - Zhang, Xiaoju

AU - Pan, Yuxi

AU - Gu, Niufan

AU - Feng, Guoyin

AU - He, Lin

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