NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

C. Geoffrey Lau, R. Suzanne Zukin

Research output: Contribution to journalReview article

768 Scopus citations

Abstract

The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. Neuronal activity drives not only NMDAR synaptic targeting and incorporation, but also receptor retrieval, differential sorting into the endosomal-lysosomal pathway and lateral diffusion between synaptic and extrasynaptic sites. An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.

Original languageEnglish (US)
Pages (from-to)413-426
Number of pages14
JournalNature Reviews Neuroscience
Volume8
Issue number6
DOIs
StatePublished - Jun 1 2007

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ASJC Scopus subject areas

  • Neuroscience(all)

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