TY - JOUR
T1 - NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
AU - Lau, C. Geoffrey
AU - Zukin, R. Suzanne
N1 - Funding Information:
The authors thank D. P. Purpura, M. V. L. Bennett, A. Z. Harris, B. D. Heifets, Y. R. Chin and members of the Zukin laboratory for reading earlier versions of the manuscript. Work supported by National Institutes of Health grant NS20752 to R.S.Z.
PY - 2007/6
Y1 - 2007/6
N2 - The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. Neuronal activity drives not only NMDAR synaptic targeting and incorporation, but also receptor retrieval, differential sorting into the endosomal-lysosomal pathway and lateral diffusion between synaptic and extrasynaptic sites. An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.
AB - The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. Neuronal activity drives not only NMDAR synaptic targeting and incorporation, but also receptor retrieval, differential sorting into the endosomal-lysosomal pathway and lateral diffusion between synaptic and extrasynaptic sites. An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.
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U2 - 10.1038/nrn2153
DO - 10.1038/nrn2153
M3 - Review article
C2 - 17514195
AN - SCOPUS:34249099711
SN - 1471-003X
VL - 8
SP - 413
EP - 426
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 6
ER -