@article{89b99492b0004470a4e38505b912003a,
title = "NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response",
abstract = "Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8+ T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1.1+ CD8+ T cells are derived from CD8+ T cells during priming, and their differentiation is inhibited by transforming growth factor-β signalling. After their own contraction phase, they form a distinct pool of KLRG1 CD127 double-positive memory T cells and rapidly produce both interferon-γ and granzyme B, providing significant pathogen protection in an antigen-independent manner within only a few hours. Thus, by prolonging the CD8+ T-cell response at the effector stage and by expressing exacerbated innate-like features at the memory stage, NK1.1+ cells represent a distinct subset of CD8+ T cell that contributes to the early control of microbial pathogen re-infections.",
author = "Ruiz, {Anne L.} and Soudja, {Saidi M.Homa} and Cyril Deceneux and Gr{\'e}goire Lauvau and Marie, {Julien C.}",
note = "Funding Information: We thank M. McCarron, C. Havenar-Daughton and A. Hennino for their comments. The technical assistance of J.-F. Henry, J. Noiret, C. Maisin, C. Faure, C. Garcia and A. Barbaz is acknowledged. We thank C.B. Wilson, L for CD4-Cre, as well as R. Ahmed and H. Shen for providing us with LCMV and Listeria monocytogenes, respectively. Tetramers were kindly provided by the NIH Tetramer facility (NIH, USA). We also thank all the members of our laboratories for advice and helpful discussion as well as Sarah Kabani for editing the manuscript and Cl{\'e}mentine Favrot for drawing the cover-art. This work was supported by grants from ANR-08-JCJC-0005-01 (JM), InCa Atip-Avenir program (JCM), FRM INE20091217951 (JCM), le comit{\'e} du Rhone ligue (JCM), ANR investissement d{\textquoteright}avenir ANR-10-LABX-61 (JCM). A.L.R. was supported by the Bettencourt-Schueller foundation and the Helmholtz-association. This work was also supported by institutional funds of the Albert Einstein College of Medicine of Yeshiva University (to G.L.), the National Institute of Health (Grants R21AI095835 and R01AI103338, to G.L.). Core resources that facilitated flow cytometry were supported by the Einstein Cancer Center (NCI cancer center support grant 2P30CA013330). J.C.M. is an Helmholtz-Association investigator.",
year = "2014",
doi = "10.1038/ncomms6150",
language = "English (US)",
volume = "5",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}