NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response

Anne L. Ruiz, Saidi M Homa Soudja, Cyril Deceneux, Gregoire Lauvau, Julien C. Marie

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Following microbial pathogen invasion, one of the main challenges for the host is to rapidly control pathogen spreading to avoid vital tissue damage. Here we report that an effector CD8+ T-cell population that expresses the marker NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. NK1.1+ CD8+ T cells are derived from CD8+ T cells during priming, and their differentiation is inhibited by transforming growth factor-β signalling. After their own contraction phase, they form a distinct pool of KLRG1 CD127 double-positive memory T cells and rapidly produce both interferon-γ and granzyme B, providing significant pathogen protection in an antigen-independent manner within only a few hours. Thus, by prolonging the CD8+ T-cell response at the effector stage and by expressing exacerbated innate-like features at the memory stage, NK1.1+ cells represent a distinct subset of CD8+ T cell that contributes to the early control of microbial pathogen re-infections.

Original languageEnglish (US)
Article number5150
JournalNature Communications
Volume5
DOIs
StatePublished - 2014

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T-cells
pathogens
Pathogens
escape
T-Lymphocytes
effectors
contraction
Granzymes
interferon
priming
Data storage equipment
Transforming Growth Factors
T-Lymphocyte Subsets
Interferons
antigens
infectious diseases
markers
set theory
Antigens
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response. / Ruiz, Anne L.; Soudja, Saidi M Homa; Deceneux, Cyril; Lauvau, Gregoire; Marie, Julien C.

In: Nature Communications, Vol. 5, 5150, 2014.

Research output: Contribution to journalArticle

Ruiz, Anne L. ; Soudja, Saidi M Homa ; Deceneux, Cyril ; Lauvau, Gregoire ; Marie, Julien C. / NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response. In: Nature Communications. 2014 ; Vol. 5.
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