Nitric oxide synthase distribution in the goldfish Mauthner cell

Theodore D. Bell, Alberto E. Pereda, Donald S. Faber

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

NADPH-diaphorase histochemical staining was used to assess the distribution of the enzyme nitric oxide synthase (NOS) in the goldfish brain, with the emphasis on the Mauthner (M-) cell, a reticulospinal neuron, and its inputs. Labeling was specific for certain cell types, including the M-cell, which stained heavily. The reaction product in this neuron was uniformly distributed along its axon, soma, and ventral and lateral dendrites. Afferents which synapse with the M-cell were also NADPH-diaphorase positive, including an identified class of inhibitory interneurons and the large myelinated club endings (LMCE) of eighth nerve fibers. The presence of NADPH-diaphorase in a lower level brainstem circuit that undergoes activity-dependent long-term potentiation of both excitatory and inhibitory synapses and is accessible for morpho-functional correlations provides the opportunity to elucidate the mechanism and role of nitric oxide at the single cell level.

Original languageEnglish (US)
Pages (from-to)187-190
Number of pages4
JournalNeuroscience Letters
Volume226
Issue number3
DOIs
StatePublished - May 2 1997
Externally publishedYes

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Keywords

  • Mauthner cell
  • NADPH-diaphorase
  • long-term potentiation
  • nitric oxide
  • nitric oxide synthase

ASJC Scopus subject areas

  • Neuroscience(all)

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