Nitric Oxide-Releasing Nanoparticles as an Antimicrobial Therapeutic

Jamie Rosen, Angelo Landriscina, Joshua D. Nosanchuk

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The development of new antimicrobial agents has fallen behind microbial drug resistance, posing a significant challenge for combating infectious disease. Nanotherapeutics have revolutionized antimicrobial therapy, providing new mechanisms to combat microbial resistance. Nitric oxide (NO), a simple gaseous molecule with ubiquitous biological activity, represents one such strategy as its antimicrobial properties are well described. Harnessing this potential has proven difficult given the lack of effective delivery vehicles. However, this challenge has been overcome by the generation of a nanoparticulate system capable of generating physiologic concentrations of NO over time. The efficacy of these platforms against bacteria and fungi has been shown in a variety of studies. Here, we review the role of NO-releasing nanoparticulate platforms as an antimicrobial therapeutic agent.

Original languageEnglish (US)
Title of host publicationNanoscience in Dermatology
PublisherElsevier Inc.
Pages127-134
Number of pages8
ISBN (Electronic)9780128029459
ISBN (Print)9780128029268
DOIs
StatePublished - Aug 25 2016

Keywords

  • Antimicrobial
  • Nanoparticles
  • Nanotechnology
  • Nitric oxide
  • Nitric-oxide releasing platforms
  • Novel therapeutics

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Rosen, J., Landriscina, A., & Nosanchuk, J. D. (2016). Nitric Oxide-Releasing Nanoparticles as an Antimicrobial Therapeutic. In Nanoscience in Dermatology (pp. 127-134). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802926-8.00010-0