Nitric oxide releasing nanoparticles are therapeutic for Acinetobacter baumannii wound infections

Mircea Radu Mihu, Uriel Sandkovsky, George Han, Joel M. Friedman, Joshua D. Nosanchuk, Luis R. Martinez

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Acinetobacter baumannii (Ab) is a frequent cause of hospital acquired pneumonia and recently has increased in incidence as the causative agent of severe disease in troops wounded in Afghanistan and Iraq. Ab clinical isolates are frequently extremely resistant to antimicrobials, significantly complicating our capacity to treat infections due to this pathogen. Hence, the development of innovative therapeutics targeting mechanisms to which the bacteria are unlikely to evolve resistance is urgently needed. We examined the capacity of a nitric oxide-releasing nanoparticle (NO-np) to treat wounds infected with Ab. We found that the NO-nps were therapeutic in an experimental Ab murine wound model. Treatment with NO-nps significantly accelerated healing of infected wounds. Histological study demonstrated that NO-np treatment reduced suppurative inflammation, decreased microbial burden and reduced the degradation of collagen. Furthermore, NO-np treatment alters the local cytokine milieu. In sum, we demonstrated that the NO-nps are an easily administered topical antimicrobial for the treatment of Ab wound infections, and our findings suggest that NO-nps may also be ideal for use in combat or disaster situations.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalVirulence
Volume1
Issue number2
StatePublished - Mar 2010

Fingerprint

Acinetobacter baumannii
Wound Infection
Nanoparticles
Nitric Oxide
Therapeutics
Afghanistan
Iraq
Wounds and Injuries
Disasters
Wound Healing
Pneumonia
Collagen
Cytokines
Inflammation
Bacteria
Incidence
Infection

Keywords

  • Acinetobacter baumanii
  • Cytokine
  • Nanoparticles
  • Nitric oxide
  • Wound infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology
  • Parasitology
  • Immunology
  • Microbiology (medical)

Cite this

Nitric oxide releasing nanoparticles are therapeutic for Acinetobacter baumannii wound infections. / Mihu, Mircea Radu; Sandkovsky, Uriel; Han, George; Friedman, Joel M.; Nosanchuk, Joshua D.; Martinez, Luis R.

In: Virulence, Vol. 1, No. 2, 03.2010, p. 62-67.

Research output: Contribution to journalArticle

Mihu, Mircea Radu ; Sandkovsky, Uriel ; Han, George ; Friedman, Joel M. ; Nosanchuk, Joshua D. ; Martinez, Luis R. / Nitric oxide releasing nanoparticles are therapeutic for Acinetobacter baumannii wound infections. In: Virulence. 2010 ; Vol. 1, No. 2. pp. 62-67.
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