Nitric oxide releasing nanoparticle synthesis and characterization.

George Han, Adam J. Friedman, Joel M. Friedman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

While the potential applications of nitric oxide for both understanding human physiology and treating disease are far reaching, the development of a reliable, cost-effective, and practical sustained delivery system for nitric oxide has yet to emerge. Using a sol-gel/glass hybrid system, we have demonstrated controlled, sustained release of nitric oxide from a stable, dry powder. Upon exposure to an aqueous environment, the material begins releasing therapeutic levels of nitric oxide over several hours to days, making it an ideal material for evaluation of nitric oxide efficacy for both clinical and research applications.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalMethods in molecular biology (Clifton, N.J.)
Volume704
StatePublished - 2011
Externally publishedYes

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Nanoparticles
Nitric Oxide
Polymethyl Methacrylate
Powders
Glass
Gels
Costs and Cost Analysis
Research
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nitric oxide releasing nanoparticle synthesis and characterization. / Han, George; Friedman, Adam J.; Friedman, Joel M.

In: Methods in molecular biology (Clifton, N.J.), Vol. 704, 2011, p. 187-195.

Research output: Contribution to journalArticle

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