Nitric oxide generating/releasing materials

HongYing Liang, Parimala Nacharaju, Adam Friedman, Joel M. Friedman

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Harnessing the impressive therapeutic potential of Nitric oxide (NO) remains an ongoing challenge. This paper describes several of the current strategies both with respect to the underlying chemistry and physics and to the applications where they have shown promise. Included in this overview are molecular systems such as NONOates that release NO through chemical reactions and delivery vehicles such as nanoparticles that can generate, store, transport and deliver NO and related bioactive forms of NO such as nitrosothiols. Although there has been much positive movement, it is clear that we are only at the early stages of knowing how to precisely produce, transport and deliver to targeted sites therapeutic levels of NO and related molecules.

Original languageEnglish (US)
Article numberFSO54
JournalFuture Science OA
Volume1
Issue number1
DOIs
StatePublished - Aug 2015

Keywords

  • NO
  • NONOates
  • liposomes
  • nanoparticles
  • nitrosothiols

ASJC Scopus subject areas

  • Biotechnology

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