Nitric oxide from nanoparticles and applications to cardiovascular health

Pedro Cabrales, Adam J. Friedman, Joel M. Friedman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The current limitations of nitric oxide (NO) delivery systems has stimulated an extraordinary interest in the development of platforms that generate and release NO in a controlled and sustained manner, with a heavy emphasis on the treatment of cardiovascular disease states. This chapter describes the positive achievements of NO-releasing nanoparticles (NO-np) prepared using a novel platform based on hydrogel/glass hybrid nanoparticles capable of storing significant amounts of NO generated through thermal reduction of nitrite. The simplicity of the control release rate of NO from NO-np is regulated by its hydration when exposed to moisture; therefore, it allows the nanoparticles to slowly release therapeutic levels of NO. In a dose-dependent manner, infusion of NO-np has significant direct cardiovascular effect on physiological conditions, in terms of decreasing blood pressure, increasing exhaled NO, inducing vasodilation and increasing microvascular perfusion, during several hours post-infusion. Furthermore, the NO released by the NO-np prevents the inflammatory response regenerated by immune response to macroscopic external agents in the circulation. In pathological conditions related to an increase in acellular Hb in circulation, NO-np are able to prevent negative cardiovascular reactions related to NO scavenging by the acellular Hb. Furthermore, the NO-np are capable of preventing the cardiovascular collapse related to decrease in NO generation after severe hemorrhage without fluid resuscitation. These implications suggest that NO release from NO-np is advantageous over other NO-releasing compounds, because it does not depend on chemical decomposition or enzymatic catalysis. On the basis of the observed physiological properties, NO-np has clear potential as a therapeutic agent and as a research tool to increase our understanding of NO signaling mechanisms within the cardiovascular system.

Original languageEnglish (US)
Title of host publicationNanomedicine and the Cardiovascular System
PublisherCRC Press
Pages407-426
Number of pages20
ISBN (Electronic)9781439879894
ISBN (Print)9781578087266
StatePublished - Jan 1 2011

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ASJC Scopus subject areas

  • Medicine(all)
  • Engineering(all)

Cite this

Cabrales, P., Friedman, A. J., & Friedman, J. M. (2011). Nitric oxide from nanoparticles and applications to cardiovascular health. In Nanomedicine and the Cardiovascular System (pp. 407-426). CRC Press.