Nipping at cardiac remodeling

Russell S. Whelan, Kartik Mani, Richard N. Kitsis

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size (see the related article beginning on page 2825).

Original languageEnglish (US)
Pages (from-to)2751-2753
Number of pages3
JournalJournal of Clinical Investigation
Volume117
Issue number10
DOIs
Publication statusPublished - Oct 1 2007

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ASJC Scopus subject areas

  • Medicine(all)

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