Nigral muscimol infusions facilitate the development of seizures in immature rats

Solomon L. Moshé, Bruce J. Albala

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Since recent data utilizing GABAergic stimulation of the substantia nigra (SN) suggest that the SN is a crucial site in a circuitry involved in the modification of seizures in adult rats, the role of the SN was investigated in seizures of rat pups. Bilateral nigral infusions of the GABA agonist muscimol partially protected adult rats against flurothyl-induced seizures, while similar infusions actually facilitated the development of flurothyl seizures in 15-day-old rat pups. These results suggest that age-related differences in the nigral GABA sensitive system may account for the increased susceptibility to generalized seizures of the developing brain.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalDevelopmental Brain Research
Volume13
Issue number2
DOIs
StatePublished - Apr 1984

Keywords

  • GABA agonists
  • animal suckling
  • epilepsy
  • flurothyl
  • rats
  • rotational behavior
  • seizures
  • substantia nigra

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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