Nigral muscimol infusions facilitate the development of seizures in immature rats

Solomon L. Moshé; Bruce J. Albala

doi:10.1016/0165-3806(84)90165-2

Nigral muscimol infusions facilitate the development of seizures in immature rats

Solomon L. Moshé, Bruce J. Albala

Neurology

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Since recent data utilizing GABAergic stimulation of the substantia nigra (SN) suggest that the SN is a crucial site in a circuitry involved in the modification of seizures in adult rats, the role of the SN was investigated in seizures of rat pups. Bilateral nigral infusions of the GABA agonist muscimol partially protected adult rats against flurothyl-induced seizures, while similar infusions actually facilitated the development of flurothyl seizures in 15-day-old rat pups. These results suggest that age-related differences in the nigral GABA sensitive system may account for the increased susceptibility to generalized seizures of the developing brain.

Original language	English (US)
Pages (from-to)	305-308
Number of pages	4
Journal	Developmental Brain Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(84)90165-2
State	Published - Apr 1984

Keywords

GABA agonists
animal suckling
epilepsy
flurothyl
rats
rotational behavior
seizures
substantia nigra

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(84)90165-2

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abstract = "Since recent data utilizing GABAergic stimulation of the substantia nigra (SN) suggest that the SN is a crucial site in a circuitry involved in the modification of seizures in adult rats, the role of the SN was investigated in seizures of rat pups. Bilateral nigral infusions of the GABA agonist muscimol partially protected adult rats against flurothyl-induced seizures, while similar infusions actually facilitated the development of flurothyl seizures in 15-day-old rat pups. These results suggest that age-related differences in the nigral GABA sensitive system may account for the increased susceptibility to generalized seizures of the developing brain.",

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AU - Albala, Bruce J.

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AB - Since recent data utilizing GABAergic stimulation of the substantia nigra (SN) suggest that the SN is a crucial site in a circuitry involved in the modification of seizures in adult rats, the role of the SN was investigated in seizures of rat pups. Bilateral nigral infusions of the GABA agonist muscimol partially protected adult rats against flurothyl-induced seizures, while similar infusions actually facilitated the development of flurothyl seizures in 15-day-old rat pups. These results suggest that age-related differences in the nigral GABA sensitive system may account for the increased susceptibility to generalized seizures of the developing brain.

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Nigral muscimol infusions facilitate the development of seizures in immature rats

Abstract

Keywords

ASJC Scopus subject areas

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