Niches for Hematopoietic Stem Cells and Their Progeny

Qiaozhi Wei, Paul S. Frenette

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

Steady-state hematopoietic stem cells’ (HSCs) self-renewal and differentiation toward their mature progeny in the adult bone marrow is tightly regulated by cues from the microenvironment. Recent insights into the cellular and molecular constituents have uncovered a high level of complexity. Here, we review emerging evidence showing how HSCs and their progeny are regulated by an interdependent network of mesenchymal stromal cells, nerve fibers, the vasculature, and also other hematopoietic cells. Understanding the interaction mechanisms in these intricate niches will provide great opportunities for HSC-related therapies and immune modulation. The adult bone marrow provides essential niches for hematopoietic stem cell (HSC) maintenance and differentiation, which are not fully understood. Here we review the currently known cellular and molecular components of the niche for hematopoietic stem cells and their progeny, highlight their heterogeneity and interdependency, and discuss some open questions in the field.

Original languageEnglish (US)
Pages (from-to)632-648
Number of pages17
JournalImmunity
Volume48
Issue number4
DOIs
StatePublished - Apr 17 2018

Keywords

  • bone marrow niche
  • hematopoietic stem cells
  • microenvironment
  • progenitors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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