Niche heterogeneity in the bone marrow

Alexander Birbrair, Paul S. Frenette

Research output: Contribution to journalReview articlepeer-review

193 Scopus citations


In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self-renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy specific locations in the bone marrow (BM) microenvironment. The specific microenvironment regulating HSCs, commonly referred to as the niche, comprises multiple cell types whose exact contributions are under active investigation. Understanding cellular cross talk involving HSCs in the BM microenvironment is of fundamental importance for harnessing therapies against benign and malignant blood diseases. In this review, we summarize and evaluate recent advances in our understanding of niche heterogeneity and its influence on HSC function.

Original languageEnglish (US)
Pages (from-to)82-96
Number of pages15
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Apr 1 2016


  • BM
  • microenvironment
  • niche
  • stem cells

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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