TY - JOUR
T1 - NGF and nitrosative stress in patients with Huntington's disease
AU - Tasset, Inmaculada
AU - Sánchez-López, Fernando
AU - Agüera, Eduardo
AU - Fernández-Bolaños, Ricardo
AU - Sánchez, Francisco Manuel
AU - Cruz-Guerrero, Antonio
AU - Gascón-Luna, Felix
AU - Túnez, Isaac
PY - 2012/4/15
Y1 - 2012/4/15
N2 - Introduction: Huntington's disease (HD) is a neurodegenerative genetic disorder caused by expansion of polyglutamine repeats in the huntingtin gene and characterised by the loss of striatal and cortical neurons. Few studies to date have focussed on peripheral neurotrophic-factor levels in patients with HD. Objective: To measure plasma NGF levels in Huntington's disease and investigate their correlation with disease intensity. Materials and methods: Nineteen patients with HD and nineteen age- and sex-matched healthy subjects took part in this cross-sectional study. Plasma levels of NGF, BDNF, GDNF, nitrotyrosine, and myeloperoxidase (MPO) were measured; lactate dehydrogenase (LDH) levels were determined and white blood cell (WBC) counts were evaluated. Results: NGF levels were significantly lower, nitrotyrosine levels were higher and LDH activity was greater in HD patients than in healthy subjects. There was no significant difference in MPO levels or WBC counts, whereas the MPO/WBC ratio was considerably higher in HD patients. The data obtained suggested that biochemical and haematological changes correlated with disease severity. Conclusion: NGF levels are lower in HD patients than in healthy subjects. However, further research is required to confirm the role of NGF in HD.
AB - Introduction: Huntington's disease (HD) is a neurodegenerative genetic disorder caused by expansion of polyglutamine repeats in the huntingtin gene and characterised by the loss of striatal and cortical neurons. Few studies to date have focussed on peripheral neurotrophic-factor levels in patients with HD. Objective: To measure plasma NGF levels in Huntington's disease and investigate their correlation with disease intensity. Materials and methods: Nineteen patients with HD and nineteen age- and sex-matched healthy subjects took part in this cross-sectional study. Plasma levels of NGF, BDNF, GDNF, nitrotyrosine, and myeloperoxidase (MPO) were measured; lactate dehydrogenase (LDH) levels were determined and white blood cell (WBC) counts were evaluated. Results: NGF levels were significantly lower, nitrotyrosine levels were higher and LDH activity was greater in HD patients than in healthy subjects. There was no significant difference in MPO levels or WBC counts, whereas the MPO/WBC ratio was considerably higher in HD patients. The data obtained suggested that biochemical and haematological changes correlated with disease severity. Conclusion: NGF levels are lower in HD patients than in healthy subjects. However, further research is required to confirm the role of NGF in HD.
KW - BDNF
KW - Basal ganglia
KW - GDNF
KW - Huntington's disease
KW - NGF
KW - Neurodegeneration
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U2 - 10.1016/j.jns.2011.12.014
DO - 10.1016/j.jns.2011.12.014
M3 - Article
C2 - 22251933
AN - SCOPUS:84857996311
SN - 0022-510X
VL - 315
SP - 133
EP - 136
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -