NFAT proteins: Key regulators of T-cell development and function

Research output: Contribution to journalArticle

882 Citations (Scopus)

Abstract

Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance, The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.

Original languageEnglish (US)
Pages (from-to)472-484
Number of pages13
JournalNature Reviews Immunology
Volume5
Issue number6
DOIs
StatePublished - Jun 2005

Fingerprint

NFATC Transcription Factors
T-Lymphocytes
Proteins
TCF Transcription Factors
Self Tolerance
Calcium Signaling
Thymocytes
Cell Differentiation
Immune System
Transcription Factors

ASJC Scopus subject areas

  • Immunology

Cite this

NFAT proteins : Key regulators of T-cell development and function. / Macian-Juan, Fernando.

In: Nature Reviews Immunology, Vol. 5, No. 6, 06.2005, p. 472-484.

Research output: Contribution to journalArticle

@article{7654ca51194f4a2680b0491125833efe,
title = "NFAT proteins: Key regulators of T-cell development and function",
abstract = "Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance, The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.",
author = "Fernando Macian-Juan",
year = "2005",
month = "6",
doi = "10.1038/nri1632",
language = "English (US)",
volume = "5",
pages = "472--484",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - NFAT proteins

T2 - Key regulators of T-cell development and function

AU - Macian-Juan, Fernando

PY - 2005/6

Y1 - 2005/6

N2 - Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance, The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.

AB - Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of transcription factors has grown to include five members. It has also become clear that NFAT proteins have crucial roles in the development and function of the immune system. In T cells, NFAT proteins not only regulate activation but also are involved in the control of thymocyte development, T-cell differentiation and self-tolerance, The functional versatility of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T cells.

UR - http://www.scopus.com/inward/record.url?scp=20644466433&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20644466433&partnerID=8YFLogxK

U2 - 10.1038/nri1632

DO - 10.1038/nri1632

M3 - Article

C2 - 15928679

AN - SCOPUS:20644466433

VL - 5

SP - 472

EP - 484

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 6

ER -