NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Obesity, type 2 diabetes, and the associated metabolic syndrome are known as the aggregate products from nutritional excess, and have become huge epidemics and represent public health problems in the developed world. Yet, there exist few successful approaches for the treatment and prevention of these complex diseases, in part because they are not well understood at the molecular levels. Recent research has revealed that many nutrient- and pathogen-sensing systems can be highly integrated, positing the regulatory system of immune response at the mechanistic interface between metabolic regulation and the development of overnutrition-related diseases. The underlying molecular processes have been associated with the basis of how nutritional changes trigger atypical inflammation and how metabolic inflammation affects the signaling and functions of metabolic tissues and cells. In this endeavor, the pro-inflammatory axis consisting of the nuclear transcription factor NFκB and its upstream kinase IKKκ has been identified as one critical mediator that is responsible for nutritionally-induced inflammation, and a large body of research has been documented to support the concept that IKKβ/NFκB represents a general cause of various metabolic dysfunctions under overnutrition. Here, we comparatively review the tissue-specific programs and actions of IKKβ/NFκB in causing and promoting overnutrition-related diseases.

Original languageEnglish (US)
Pages (from-to)2542-2548
Number of pages7
JournalCell Cycle
Volume8
Issue number16
StatePublished - Aug 15 2009

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Overnutrition
Central Nervous System
Inflammation
Research
Type 2 Diabetes Mellitus
Immune System
Transcription Factors
Phosphotransferases
Public Health
Obesity
Food
Therapeutics

Keywords

  • Hypothalamus
  • Insulin resistance
  • Metabolic syndrome
  • NFκB
  • Obesity

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology
  • Medicine(all)

Cite this

NFκB-mediated metabolic inflammation in peripheral tissues versus central nervous system. / Cai, Dongsheng.

In: Cell Cycle, Vol. 8, No. 16, 15.08.2009, p. 2542-2548.

Research output: Contribution to journalArticle

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