TY - JOUR
T1 - Newly identified roles of PML in stem cell biology
AU - Ito, Kyoko
AU - Ito, Keisuke
PY - 2013
Y1 - 2013
N2 - It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute PML (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprograming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical "rheostat" responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications.
AB - It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute PML (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprograming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical "rheostat" responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications.
KW - Breast cancer
KW - Metabolism
KW - PML
KW - Stem cells
KW - Stem cells and differentiation
UR - http://www.scopus.com/inward/record.url?scp=84890756284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890756284&partnerID=8YFLogxK
U2 - 10.3389/fonc.2013.00050
DO - 10.3389/fonc.2013.00050
M3 - Short survey
AN - SCOPUS:84890756284
SN - 2234-943X
VL - 3 MAR
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - Article 00050
ER -