Newly identified roles of PML in stem cell biology

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It has long been believed that the tumor suppressor promyelocytic leukemia (PML), the core component of the nuclear substructures known as the PML-nuclear bodies, plays a key part in acute PML (APL), as it is first cloned at the breakpoint of the t(15;17) translocation typical of that disease. Research over the past decade, however, has radically changed our view of how this tumor suppressor is regulated, how it can be therapeutically targeted, and how it functions in a number of tissue systems. One noteworthy recent study, for instance, revealed that PML regulates the activation of fatty acid metabolism, and that this metabolic reprograming plays an essential role in cancer biology and stem cell biology through the control it exerts over stem cell fate decisions. These findings sparked exciting new investigations of PML as a critical "rheostat" responsible for fine-tuning tissue homeostasis, and thus created at the intersection of cancer and stem cell biology a new field of study with important therapeutic implications.

Original languageEnglish (US)
Article numberArticle 00050
JournalFrontiers in Oncology
Volume3 MAR
DOIs
StatePublished - 2013

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Cell Biology
Leukemia
Stem Cells
Neoplastic Stem Cells
Acute Promyelocytic Leukemia
Neoplasms
Homeostasis
Fatty Acids
Research
Therapeutics

Keywords

  • Breast cancer
  • Metabolism
  • PML
  • Stem cells
  • Stem cells and differentiation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Newly identified roles of PML in stem cell biology. / Ito, Kyoko; Ito, Keisuke.

In: Frontiers in Oncology, Vol. 3 MAR, Article 00050, 2013.

Research output: Contribution to journalArticle

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