Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration

Oren M. Tepper, Brett A. Sealove, Toshinori Murayama, Takayuki Asahara

Research output: Contribution to journalReview article

27 Scopus citations


It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalJournal of Investigative Medicine
Issue number6
Publication statusPublished - Nov 2003
Externally publishedYes



  • Angiogenesis
  • Cell/gene therapy
  • Endothelial progenitor cells
  • Therapeutic vasculogenesis
  • Vasculogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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