Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration

Oren M. Tepper, Brett A. Sealove, Toshinori Murayama, Takayuki Asahara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalJournal of Investigative Medicine
Volume51
Issue number6
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Tissue regeneration
Endothelial cells
Blood vessels
Blood Vessels
Regeneration
Growth
Ischemia
Endothelial Cells
Bone Marrow
Cytokines
Bone
Tissue
Endothelial Progenitor Cells
Therapeutics

Keywords

  • Angiogenesis
  • Cell/gene therapy
  • Endothelial progenitor cells
  • Therapeutic vasculogenesis
  • Vasculogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Newly Emerging Concepts in Blood Vessel Growth : Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration. / Tepper, Oren M.; Sealove, Brett A.; Murayama, Toshinori; Asahara, Takayuki.

In: Journal of Investigative Medicine, Vol. 51, No. 6, 11.2003, p. 353-359.

Research output: Contribution to journalArticle

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