Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration

Oren M. Tepper; Brett A. Sealove; Toshinori Murayama; Takayuki Asahara

doi:10.1136/jim-51-06-31

Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration

Oren M. Tepper, Brett A. Sealove, Toshinori Murayama, Takayuki Asahara

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.

Original language	English (US)
Pages (from-to)	353-359
Number of pages	7
Journal	Journal of Investigative Medicine
Volume	51
Issue number	6
DOIs	https://doi.org/10.1136/jim-51-06-31
State	Published - Nov 2003
Externally published	Yes

Keywords

Angiogenesis
Cell/gene therapy
Endothelial progenitor cells
Therapeutic vasculogenesis
Vasculogenesis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1136/jim-51-06-31

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title = "Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration",

abstract = "It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.",

keywords = "Angiogenesis, Cell/gene therapy, Endothelial progenitor cells, Therapeutic vasculogenesis, Vasculogenesis",

author = "Tepper, {Oren M.} and Sealove, {Brett A.} and Toshinori Murayama and Takayuki Asahara",

year = "2003",

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T2 - Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration

AU - Tepper, Oren M.

AU - Sealove, Brett A.

AU - Murayama, Toshinori

AU - Asahara, Takayuki

PY - 2003/11

Y1 - 2003/11

N2 - It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.

AB - It has recently been established that bone marrow-derived endothelial progenitor cells (EPCs) are recruited to the systemic circulation and, in response to various cytokines, pharmacologic agents, and/or tissue ischemia, incorporate into sites of new blood vessel growth (neovascularization). These findings have changed our understanding of adult neovascularization by demonstrating that both preexisting endothelial cells and EPCs contribute to blood vessel formation during adult life. The following review article highlights the discovery of EPCs, their relationship to various clinical diseases, and their therapeutic potential for augmenting blood vessel formation.

KW - Angiogenesis

KW - Cell/gene therapy

KW - Endothelial progenitor cells

KW - Therapeutic vasculogenesis

KW - Vasculogenesis

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Newly Emerging Concepts in Blood Vessel Growth: Recent Discovery of Endothelial Progenitor Cells and Their Function in Tissue Regeneration

Abstract

Keywords

ASJC Scopus subject areas

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