TY - JOUR
T1 - Newly discovered KI, WU, and Merkel cell polyomaviruses
T2 - No evidence of mother-to-fetus transmission
AU - Sadeghi, Mohammadreza
AU - Riipinen, Anita
AU - Väisänen, Elina
AU - Chen, Tingting
AU - Kantola, Kalle
AU - Surcel, Heljä Marja
AU - Karikoski, Riitta
AU - Taskinen, Helena
AU - Söderlund-Venermo, Maria
AU - Hedman, Klaus
N1 - Funding Information:
This study was supported by the Helsinki University Central Hospital Research & Education and Research & Development funds, the Sigrid Jusèlius Foundation, the Medical Society of Finland (FLS), and the Academy of Finland (project code 1122539). M.S. expresses his gratitude to the Ministry of Science, Research and Technology of Iran for a research scholarship as well as to Bu-Ali Sina University, Hamedan for the opportunity to advanced studies. For friendly help with language revision we are much indebted to Carolyn Brimley Norris from language services of Helsinki University. *Note added in proof: Since the work described in this paper was completed and submitted for publication, another previously unknown human polyomavirus, TSPyV, was identified by Van der Meijden et al, (PLoS Pathog 2010;6, e1001024), bringing to six the number human polyomaviruses known.
PY - 2010
Y1 - 2010
N2 - Background: Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown. In particular, nothing is known about their preponderance in vertical transmission. The aim of this study was to investigate the frequency of fetal infections by these viruses. We sought the three by PCR, and MCPyV also by real-time quantitative PCR (qPCR), from 535 fetal autopsy samples (heart, liver, placenta) from intrauterine fetal deaths (IUFDs) (N = 169), miscarriages (120) or induced abortions (246). We also measured the MCPyV IgG antibodies in the corresponding maternal sera (N = 462) mostly from the first trimester. Results: No sample showed KIPyV or WUPyV DNA. Interestingly, one placenta was reproducibly PCR positive for MCPyV. Among the 462 corresponding pregnant women, 212 (45.9%) were MCPyV IgG seropositive. Conclusions: Our data suggest that none of the three emerging polyomaviruses often cause miscarriages or IUFDs, nor are they transmitted to fetuses. Yet, more than half the expectant mothers were susceptible to infection by the MCPyV.
AB - Background: Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown. In particular, nothing is known about their preponderance in vertical transmission. The aim of this study was to investigate the frequency of fetal infections by these viruses. We sought the three by PCR, and MCPyV also by real-time quantitative PCR (qPCR), from 535 fetal autopsy samples (heart, liver, placenta) from intrauterine fetal deaths (IUFDs) (N = 169), miscarriages (120) or induced abortions (246). We also measured the MCPyV IgG antibodies in the corresponding maternal sera (N = 462) mostly from the first trimester. Results: No sample showed KIPyV or WUPyV DNA. Interestingly, one placenta was reproducibly PCR positive for MCPyV. Among the 462 corresponding pregnant women, 212 (45.9%) were MCPyV IgG seropositive. Conclusions: Our data suggest that none of the three emerging polyomaviruses often cause miscarriages or IUFDs, nor are they transmitted to fetuses. Yet, more than half the expectant mothers were susceptible to infection by the MCPyV.
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U2 - 10.1186/1743-422X-7-251
DO - 10.1186/1743-422X-7-251
M3 - Article
C2 - 20860804
AN - SCOPUS:77957958038
SN - 1743-422X
VL - 7
JO - Virology Journal
JF - Virology Journal
M1 - 251
ER -