New use of BCG for recombinant vaccines

C. K. Stover, V. F. De La Cruz, T. R. Fuerst, J. E. Burlein, L. A. Benson, L. T. Bennett, G. P. Bansal, J. F. Young, M. H. Lee, G. F. Hatfull, S. B. Snapper, R. G. Barletta, W. R. Jacobs, B. R. Bloom

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Abstract

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalNature
Volume351
Issue number6326
DOIs
StatePublished - Jan 1 1991

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Cite this

Stover, C. K., De La Cruz, V. F., Fuerst, T. R., Burlein, J. E., Benson, L. A., Bennett, L. T., Bansal, G. P., Young, J. F., Lee, M. H., Hatfull, G. F., Snapper, S. B., Barletta, R. G., Jacobs, W. R., & Bloom, B. R. (1991). New use of BCG for recombinant vaccines. Nature, 351(6326), 456-460. https://doi.org/10.1038/351456a0