Abstract
Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and better tolerated allergen-derivatives, adjuvants and encapsulated allergens. Diverse routes of allergen immunotherapy–oral, sublingual, epicutanoeus and intralymphatic–are enabling immunotherapy for anaphylactic food allergies and pollen-food allergy syndrome, while improving the tolerability and effectiveness of aeroallergen immunotherapy. The addition of Anti-IgE therapy decreases adverse effects of subcutaneous and oral immunotherapy.
Original language | English (US) |
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Pages (from-to) | 2848-2863 |
Number of pages | 16 |
Journal | Human Vaccines and Immunotherapeutics |
Volume | 14 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2 2018 |
Keywords
- Allergen Immunotherapy
- Anti-IgE
- Epicutaneous Immunotherapy
- Oral Immunotherapy
- Subcutaneous Immunotherapy
- Sublingual Immunotherapy
- adjuvants
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Pharmacology