New modalities of allergen immunotherapy

Manish Ramesh, Merhunisa Karagic

Research output: Contribution to journalReview article

Abstract

Allergen immunotherapy is a rapidly evolving field. Although subcutaneous immunotherapy has been practiced for over a hundred years, improved understanding of the underlying immunological mechanisms has led to the development of new, efficacious and better tolerated allergen-derivatives, adjuvants and encapsulated allergens. Diverse routes of allergen immunotherapy–oral, sublingual, epicutanoeus and intralymphatic–are enabling immunotherapy for anaphylactic food allergies and pollen-food allergy syndrome, while improving the tolerability and effectiveness of aeroallergen immunotherapy. The addition of Anti-IgE therapy decreases adverse effects of subcutaneous and oral immunotherapy.

Original languageEnglish (US)
Pages (from-to)2848-2863
Number of pages16
JournalHuman Vaccines and Immunotherapeutics
Volume14
Issue number12
DOIs
StatePublished - Dec 2 2018

Keywords

  • adjuvants
  • Allergen Immunotherapy
  • Anti-IgE
  • Epicutaneous Immunotherapy
  • Oral Immunotherapy
  • Subcutaneous Immunotherapy
  • Sublingual Immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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