New medicinal properties of mangostins: Analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.

Jihong Cui, Wen Hu, Zhanjun Cai, Yingxue Liu, Siyuan Li, Wucheng Tao, Hui Xiang

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

The fruit hull of Garcinia mangostana L. contains oxygenated and prenylated phenol derivatives, such as xanthones or xanthen-9H-ones, and is used by people in Southeast Asia as a traditional medicine for the treatment of abdominal pain, dysentery, wound infections, suppuration, and chronic ulcer. We isolated the active ingredients from the crude ethanol extract of G. mangostana L. (CEM) and investigated their analgesic effects and underlying mechanisms. CEM at intragastric (i.g.) doses of 0.5, 1, and 3 g/kg clearly exhibited antinociceptive effects in the hot-plate and acetic acid-induced writhing tests in mice. Two isolated compounds, α-mangostin and γ-mangostin, exhibited analgesic effects at doses of 25 and 50 mg/kg (i.g.) in the hot-plate and formalin tests, respectively. CEM at doses of 0.5, 1, and 3 g/kg significantly inhibited xylene-induced release of inflammatory mediators. CEM, α-mangostin, and γ-mangostin each dose-dependently demonstrated the ability to scavenge reactive oxygen species. In conclusion, our results demonstrate that CEM and mangostins possess potent peripheral and central antinociceptive effects in mice and suggest that xanthones may be developed as novel analgesics and anti-inflammatory drugs.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalPharmacology Biochemistry and Behavior
Volume95
Issue number2
DOIs
StatePublished - Apr 2010
Externally publishedYes

Keywords

  • Acetic acid-induced writhing test
  • Analgesic effect
  • Anti-inflammatory activity
  • Antioxidation
  • Formalin test
  • Garcinia mangostana L.
  • Hot-plate test
  • Hydroxyl radicals
  • Superoxide radical
  • α-mangostin
  • γ-mangostin

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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