New insights on mechanisms underlying methylmercury-induced and manganese-induced neurotoxicity

Airton C. Martins, Tao Ke, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalReview articlepeer-review

Abstract

Toxic and essential elements are widely distributed in the Earth's crust and individuals may be exposed to several of them. Indeed, exposure to toxic elements such as mercury (Hg) can be a potential health risk factor of health, mainly by ingestion of fish containing methylmercury (MeHg). On the other hand, essential elements such as manganese (Mn) play an important role in the physiological process in the human body; however, Mn overexposure may cause toxic effects. In this respect, the neurotoxic effects of MeHg and Mn on the developing brain are well recognized. Therefore, in this critical review, we address the effects of MeHg and Mn on cell signaling pathways, which may contribute to molecular mechanisms involved in MeHg-induced and Mn-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalCurrent Opinion in Toxicology
Volume25
DOIs
StatePublished - Mar 2021

Keywords

  • Heavy metal
  • Manganese
  • Mercury
  • Methylmercury
  • Neurotoxicology
  • Signaling pathways

ASJC Scopus subject areas

  • Toxicology

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