New Insights into the Pathogenesis of MDS and the rational therapeutic opportunities

Abdallah Abou Zahr, Carolina Bernabe Ramirez, Jocelyn Wozney, Thomas Prebet, Amer M. Zeidan

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Myelodysplastic syndromes (MDS) include a heterogeneous group of acquired hematopoietic malignancies characterized by ineffective hematopoiesis, peripheral cytopenias, and a varying propensity for progression to acute myeloid leukemia. The clinical heterogeneity in MDS is a reflection of its molecular heterogeneity. Better understanding of aberrant epigenetics, dysregulation of immune responses, and del(5q) MDS has provided the rationale for well-established treatments in MDS. Further understanding of abnormal signal transduction and aberrant apoptosis pathways has led to development of new rational therapies that are in advanced phases of clinical translation. This review seeks to describe recent developments in our understanding of the pathogenesis of MDS and the potential therapeutic implications of these observations.

Original languageEnglish (US)
Pages (from-to)377-388
Number of pages12
JournalExpert Review of Hematology
Volume9
Issue number4
DOIs
StatePublished - Apr 2 2016
Externally publishedYes

Keywords

  • Del5q
  • DNMTI
  • Epigenetics
  • immune dysregulation
  • Myelodysplastic syndrome
  • Pathogenesis

ASJC Scopus subject areas

  • Hematology

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