New insights in cardiac calcium handling and excitation-contraction coupling

Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceedingChapter

65 Scopus citations

Abstract

Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages373-385
Number of pages13
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1067
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Calcium
  • Contraction
  • Heart Failure
  • Mitochondria
  • RyR
  • SerCa

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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