New insights in cardiac calcium handling and excitation-contraction coupling

Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca2+) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca2+ handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages373-385
Number of pages13
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1067
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Calcium
  • Contraction
  • Heart Failure
  • Mitochondria
  • RyR
  • SerCa

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'New insights in cardiac calcium handling and excitation-contraction coupling'. Together they form a unique fingerprint.

  • Cite this

    Gambardella, J., Trimarco, B., Iaccarino, G., & Santulli, G. (2018). New insights in cardiac calcium handling and excitation-contraction coupling. In Advances in Experimental Medicine and Biology (pp. 373-385). (Advances in Experimental Medicine and Biology; Vol. 1067). Springer New York LLC. https://doi.org/10.1007/5584_2017_106