New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

Maryam Mahjoubin-Tehran, Samaneh Rezaei, Amin Jesmani, Nafise Birang, Korosh Morshedi, Hashem Khanbabaei, Haroon Khan, Ashkan Piranviseh, Majid Nejati, Michael Aschner, Hamed Mirzaei

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.

Original languageEnglish (US)
Article number111753
JournalBiomedicine and Pharmacotherapy
Volume140
DOIs
StatePublished - Aug 2021

Keywords

  • Long non-coding RNAs
  • MicroRNAs
  • Pathogenesis
  • Stroke

ASJC Scopus subject areas

  • Pharmacology

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