TY - JOUR
T1 - New epigenetic players in stroke pathogenesis
T2 - From non-coding RNAs to exosomal non-coding RNAs
AU - Mahjoubin-Tehran, Maryam
AU - Rezaei, Samaneh
AU - Jesmani, Amin
AU - Birang, Nafise
AU - Morshedi, Korosh
AU - Khanbabaei, Hashem
AU - Khan, Haroon
AU - Piranviseh, Ashkan
AU - Nejati, Majid
AU - Aschner, Michael
AU - Mirzaei, Hamed
N1 - Funding Information:
The present study was funded by a grant from the Vice Chancellor for Research, Kashan University of Medical Sciences , in Iran. MA was supported in part by grants from the National Institute of Environmental Health Sciences (NIEHS) R01ES07331 and R01ES10563 .
Publisher Copyright:
© 2021 The Authors
PY - 2021/8
Y1 - 2021/8
N2 - Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.
AB - Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.
KW - Long non-coding RNAs
KW - MicroRNAs
KW - Pathogenesis
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85108373807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85108373807&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2021.111753
DO - 10.1016/j.biopha.2021.111753
M3 - Review article
C2 - 34044272
AN - SCOPUS:85108373807
SN - 0753-3322
VL - 140
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 111753
ER -