New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

Maryam Mahjoubin-Tehran; Samaneh Rezaei; Amin Jesmani; Nafise Birang; Korosh Morshedi; Hashem Khanbabaei; Haroon Khan; Ashkan Piranviseh; Majid Nejati; Michael Aschner; Hamed Mirzaei

doi:10.1016/j.biopha.2021.111753

New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

Maryam Mahjoubin-Tehran, Samaneh Rezaei, Amin Jesmani, Nafise Birang, Korosh Morshedi, Hashem Khanbabaei, Haroon Khan, Ashkan Piranviseh, Majid Nejati, Michael Aschner, Hamed Mirzaei

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.

Original language	English (US)
Article number	111753
Journal	Biomedicine and Pharmacotherapy
Volume	140
DOIs	https://doi.org/10.1016/j.biopha.2021.111753
State	Published - Aug 2021

Keywords

Long non-coding RNAs
MicroRNAs
Pathogenesis
Stroke

ASJC Scopus subject areas

Pharmacology

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10.1016/j.biopha.2021.111753

Cite this

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title = "New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs",

abstract = "Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.",

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doi = "10.1016/j.biopha.2021.111753",

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T2 - From non-coding RNAs to exosomal non-coding RNAs

AU - Mahjoubin-Tehran, Maryam

AU - Rezaei, Samaneh

AU - Jesmani, Amin

AU - Birang, Nafise

AU - Morshedi, Korosh

AU - Khanbabaei, Hashem

AU - Khan, Haroon

AU - Piranviseh, Ashkan

AU - Nejati, Majid

AU - Aschner, Michael

AU - Mirzaei, Hamed

PY - 2021/8

Y1 - 2021/8

N2 - Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.

AB - Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke.

KW - Long non-coding RNAs

KW - MicroRNAs

KW - Pathogenesis

KW - Stroke

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New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs

Abstract

Keywords

ASJC Scopus subject areas

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