New approaches to in-cell detection of protein activity: Genetically encoded chemiluminescence probes pave the way to robust HTS assays

Research output: Contribution to journalShort survey

3 Scopus citations


New genetically encoded biosensors utilizing the modified firefly luciferase promise a great improvement in the signal-to-noise ratio and the dynamic range of response in living cells. These biosensors are particularly suitable for high-throughput screening assays that use large-well-capacity formats because of their excellent response characteristics. The biosensor design strategies are highly generalizable and will be extremely valuable for expanding the repertoire of screenable targets in living cell systems.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalACS Chemical Biology
Issue number6
StatePublished - Jun 20 2008


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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