New anticancer agents: Recent developments in tumor therapy

Riyasat Ali, Zeenat Mirza, Ghulam M.D. Ashraf, Mohammad Amjad Kamal, Shakeel Ahmed Ansari, Ghazi Abdullah Damanhouri, Adel Mohammad Abuzenadah, Adeel Ga Chaudhary, Ishfaq Ahmed Sheikh

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents that are currently being used. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs with minimal side-effects. One important strategy to develop effective anticancer agents is to study into anticancer agents derived from natural sources. Anticancer agents derived from plants and their derivatives have been proven to be effective for cancer prevention and therapeutics. Vinca alkaloid and their derivatives, alone and in combination with therapeutic agents, have been used for a long time for the treatment of various types of cancers. Polyphenols form one of the most important and extensively used classes of plant-derived therapeutics for cancer prevention or chemotherapy. The present review highlights a plethora of studies focused on the antineoplastic properties of plant-derived chemicals, such as Vinca alkaloid, saponins, and flavonoids.

Original languageEnglish (US)
Pages (from-to)2999-3005
Number of pages7
JournalAnticancer Research
Volume32
Issue number7
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Antineoplastic Agents
Vinca Alkaloids
Neoplasms
Therapeutics
Saponins
Phytochemicals
Polyphenols
Flavonoids
Recurrence
Drug Therapy
Pharmaceutical Preparations

Keywords

  • Natural products
  • New anticancer agents
  • Plant-derived chemicals
  • Review

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ali, R., Mirza, Z., Ashraf, G. M. D., Kamal, M. A., Ansari, S. A., Damanhouri, G. A., ... Sheikh, I. A. (2012). New anticancer agents: Recent developments in tumor therapy. Anticancer Research, 32(7), 2999-3005.

New anticancer agents : Recent developments in tumor therapy. / Ali, Riyasat; Mirza, Zeenat; Ashraf, Ghulam M.D.; Kamal, Mohammad Amjad; Ansari, Shakeel Ahmed; Damanhouri, Ghazi Abdullah; Abuzenadah, Adel Mohammad; Chaudhary, Adeel Ga; Sheikh, Ishfaq Ahmed.

In: Anticancer Research, Vol. 32, No. 7, 01.07.2012, p. 2999-3005.

Research output: Contribution to journalReview article

Ali, R, Mirza, Z, Ashraf, GMD, Kamal, MA, Ansari, SA, Damanhouri, GA, Abuzenadah, AM, Chaudhary, AG & Sheikh, IA 2012, 'New anticancer agents: Recent developments in tumor therapy', Anticancer Research, vol. 32, no. 7, pp. 2999-3005.
Ali R, Mirza Z, Ashraf GMD, Kamal MA, Ansari SA, Damanhouri GA et al. New anticancer agents: Recent developments in tumor therapy. Anticancer Research. 2012 Jul 1;32(7):2999-3005.
Ali, Riyasat ; Mirza, Zeenat ; Ashraf, Ghulam M.D. ; Kamal, Mohammad Amjad ; Ansari, Shakeel Ahmed ; Damanhouri, Ghazi Abdullah ; Abuzenadah, Adel Mohammad ; Chaudhary, Adeel Ga ; Sheikh, Ishfaq Ahmed. / New anticancer agents : Recent developments in tumor therapy. In: Anticancer Research. 2012 ; Vol. 32, No. 7. pp. 2999-3005.
@article{9383704d4ecf45b091b4cb03b972ed44,
title = "New anticancer agents: Recent developments in tumor therapy",
abstract = "Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents that are currently being used. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs with minimal side-effects. One important strategy to develop effective anticancer agents is to study into anticancer agents derived from natural sources. Anticancer agents derived from plants and their derivatives have been proven to be effective for cancer prevention and therapeutics. Vinca alkaloid and their derivatives, alone and in combination with therapeutic agents, have been used for a long time for the treatment of various types of cancers. Polyphenols form one of the most important and extensively used classes of plant-derived therapeutics for cancer prevention or chemotherapy. The present review highlights a plethora of studies focused on the antineoplastic properties of plant-derived chemicals, such as Vinca alkaloid, saponins, and flavonoids.",
keywords = "Natural products, New anticancer agents, Plant-derived chemicals, Review",
author = "Riyasat Ali and Zeenat Mirza and Ashraf, {Ghulam M.D.} and Kamal, {Mohammad Amjad} and Ansari, {Shakeel Ahmed} and Damanhouri, {Ghazi Abdullah} and Abuzenadah, {Adel Mohammad} and Chaudhary, {Adeel Ga} and Sheikh, {Ishfaq Ahmed}",
year = "2012",
month = "7",
day = "1",
language = "English (US)",
volume = "32",
pages = "2999--3005",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "7",

}

TY - JOUR

T1 - New anticancer agents

T2 - Recent developments in tumor therapy

AU - Ali, Riyasat

AU - Mirza, Zeenat

AU - Ashraf, Ghulam M.D.

AU - Kamal, Mohammad Amjad

AU - Ansari, Shakeel Ahmed

AU - Damanhouri, Ghazi Abdullah

AU - Abuzenadah, Adel Mohammad

AU - Chaudhary, Adeel Ga

AU - Sheikh, Ishfaq Ahmed

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents that are currently being used. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs with minimal side-effects. One important strategy to develop effective anticancer agents is to study into anticancer agents derived from natural sources. Anticancer agents derived from plants and their derivatives have been proven to be effective for cancer prevention and therapeutics. Vinca alkaloid and their derivatives, alone and in combination with therapeutic agents, have been used for a long time for the treatment of various types of cancers. Polyphenols form one of the most important and extensively used classes of plant-derived therapeutics for cancer prevention or chemotherapy. The present review highlights a plethora of studies focused on the antineoplastic properties of plant-derived chemicals, such as Vinca alkaloid, saponins, and flavonoids.

AB - Increasing recurrence of mammalian tumors and severe side-effects of chemotherapeutic agents reduce the clinical efficacy of a large variety of anticancer agents that are currently being used. Thus, there is always a constant need to develop alternative or synergistic anticancer drugs with minimal side-effects. One important strategy to develop effective anticancer agents is to study into anticancer agents derived from natural sources. Anticancer agents derived from plants and their derivatives have been proven to be effective for cancer prevention and therapeutics. Vinca alkaloid and their derivatives, alone and in combination with therapeutic agents, have been used for a long time for the treatment of various types of cancers. Polyphenols form one of the most important and extensively used classes of plant-derived therapeutics for cancer prevention or chemotherapy. The present review highlights a plethora of studies focused on the antineoplastic properties of plant-derived chemicals, such as Vinca alkaloid, saponins, and flavonoids.

KW - Natural products

KW - New anticancer agents

KW - Plant-derived chemicals

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=84865682929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865682929&partnerID=8YFLogxK

M3 - Review article

C2 - 22753764

AN - SCOPUS:84865682929

VL - 32

SP - 2999

EP - 3005

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 7

ER -