Neutrophil migration in infection and wound repair: Going forward in reverse

Sofia De Oliveira, Emily E. Rosowski, Anna Huttenlocher

Research output: Contribution to journalReview articlepeer-review

387 Scopus citations

Abstract

Neutrophil migration and its role during inflammation has been the focus of increased interest in the past decade. Advances in live imaging and the use of new model systems have helped to uncover the behaviour of neutrophils in injured and infected tissues. Although neutrophils were considered to be short-lived effector cells that undergo apoptosis in damaged tissues, recent evidence suggests that neutrophil behaviour is more complex and, in some settings, neutrophils might leave sites of tissue injury and migrate back into the vasculature. The role of reverse migration and its contribution to resolution of inflammation remains unclear. In this Review, we discuss the different cues within tissues that mediate neutrophil forward and reverse migration in response to injury or infection and the implications of these mechanisms to human disease.

Original languageEnglish (US)
Pages (from-to)378-391
Number of pages14
JournalNature Reviews Immunology
Volume16
Issue number6
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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