Neurotoxicology

Principles and considerations of in vitro assessment

Michael Aschner, Tore Syversen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neurotoxicology is an exciting area of science, not only because of the importance of toxic injury to the nervous system in human disease, but also because specific toxicants have served as invaluable tools for the advancement of our knowledge of "normal" neurobiological processes. In fact, much of our understanding of the organisation and function of the nervous system is based on observations derived from the actions of neurotoxicants. This paper addresses various physiological aspects behind the exquisite sensitivity of the nervous system to toxic agents, including the privileged status of the nervous system vis-a-vis blood-brain barrier function, the extensions of the nervous system over space and the requirements of cells with such a complex geometry, and the transmission of information across extracellular space. In addition, in vitro models and their utility in the assessment of neurotoxicological outcome are discussed, with reference to both their advantages and disadvantages.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalATLA Alternatives to Laboratory Animals
Volume32
Issue number4
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Neurology
nervous system
Nervous System
Poisons
Nervous System Trauma
Extracellular Space
Blood-Brain Barrier
blood-brain barrier
extracellular space
toxic substances
human diseases
Outcome Assessment (Health Care)
In Vitro Techniques
Geometry
cells

Keywords

  • Astrocytes
  • Blood-brain barrier
  • Central nervous system
  • In vitro models
  • Metabolism
  • Neuron
  • Neurotoxicant
  • Neurotoxicology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Neurotoxicology : Principles and considerations of in vitro assessment. / Aschner, Michael; Syversen, Tore.

In: ATLA Alternatives to Laboratory Animals, Vol. 32, No. 4, 10.2004, p. 323-327.

Research output: Contribution to journalArticle

@article{aa748b1c03a14ebb97282e26640516a7,
title = "Neurotoxicology: Principles and considerations of in vitro assessment",
abstract = "Neurotoxicology is an exciting area of science, not only because of the importance of toxic injury to the nervous system in human disease, but also because specific toxicants have served as invaluable tools for the advancement of our knowledge of {"}normal{"} neurobiological processes. In fact, much of our understanding of the organisation and function of the nervous system is based on observations derived from the actions of neurotoxicants. This paper addresses various physiological aspects behind the exquisite sensitivity of the nervous system to toxic agents, including the privileged status of the nervous system vis-a-vis blood-brain barrier function, the extensions of the nervous system over space and the requirements of cells with such a complex geometry, and the transmission of information across extracellular space. In addition, in vitro models and their utility in the assessment of neurotoxicological outcome are discussed, with reference to both their advantages and disadvantages.",
keywords = "Astrocytes, Blood-brain barrier, Central nervous system, In vitro models, Metabolism, Neuron, Neurotoxicant, Neurotoxicology",
author = "Michael Aschner and Tore Syversen",
year = "2004",
month = "10",
language = "English (US)",
volume = "32",
pages = "323--327",
journal = "ATLA Alternatives to Laboratory Animals",
issn = "0261-1929",
publisher = "FRAME",
number = "4",

}

TY - JOUR

T1 - Neurotoxicology

T2 - Principles and considerations of in vitro assessment

AU - Aschner, Michael

AU - Syversen, Tore

PY - 2004/10

Y1 - 2004/10

N2 - Neurotoxicology is an exciting area of science, not only because of the importance of toxic injury to the nervous system in human disease, but also because specific toxicants have served as invaluable tools for the advancement of our knowledge of "normal" neurobiological processes. In fact, much of our understanding of the organisation and function of the nervous system is based on observations derived from the actions of neurotoxicants. This paper addresses various physiological aspects behind the exquisite sensitivity of the nervous system to toxic agents, including the privileged status of the nervous system vis-a-vis blood-brain barrier function, the extensions of the nervous system over space and the requirements of cells with such a complex geometry, and the transmission of information across extracellular space. In addition, in vitro models and their utility in the assessment of neurotoxicological outcome are discussed, with reference to both their advantages and disadvantages.

AB - Neurotoxicology is an exciting area of science, not only because of the importance of toxic injury to the nervous system in human disease, but also because specific toxicants have served as invaluable tools for the advancement of our knowledge of "normal" neurobiological processes. In fact, much of our understanding of the organisation and function of the nervous system is based on observations derived from the actions of neurotoxicants. This paper addresses various physiological aspects behind the exquisite sensitivity of the nervous system to toxic agents, including the privileged status of the nervous system vis-a-vis blood-brain barrier function, the extensions of the nervous system over space and the requirements of cells with such a complex geometry, and the transmission of information across extracellular space. In addition, in vitro models and their utility in the assessment of neurotoxicological outcome are discussed, with reference to both their advantages and disadvantages.

KW - Astrocytes

KW - Blood-brain barrier

KW - Central nervous system

KW - In vitro models

KW - Metabolism

KW - Neuron

KW - Neurotoxicant

KW - Neurotoxicology

UR - http://www.scopus.com/inward/record.url?scp=12344276558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344276558&partnerID=8YFLogxK

M3 - Article

VL - 32

SP - 323

EP - 327

JO - ATLA Alternatives to Laboratory Animals

JF - ATLA Alternatives to Laboratory Animals

SN - 0261-1929

IS - 4

ER -