Neurotoxicology of Metals

Roberto G. Lucchini, Michael Aschner, David C. Bellinger, Samuel W. Caito

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The nervous system has many functions, including the coordination and regulation of homeostasis of the respiratory, digestive, circulatory, and endocrine systems, to name just a few. The nervous system also controls movement and sensory perception. In addition, innate behavior originates within the nervous system, as do higher cognitive functions, which define personality and enable learning, memory, and emotions. As a result, toxicants that affect the nervous system cause broad effects across many physiological and psychological domains. Several metals, such as aluminum (Al), arsenic (As), copper (Cu), lead (Pb), manganese (Mn), mercury (Hg) and thallium (Tl), are known to be neurotoxic to the central and peripheral nervous system. There is also some evidence of neurotoxicity for alkyltin (alkyl-Sn), bismuth (Bi), cadmium (Cd), lithium (Li), selenium (Se) and zinc (Zn). From clinical neurological manifestations occurring in occupational settings, attention is now focused on preclinical neurobehavioral effects in susceptible subpopulations such as pregnant women and children. Through their long-term deposition in the body, metals may also have a role in neurodegeneration.

Original languageEnglish (US)
Title of host publicationHandbook on the Toxicology of Metals: Fourth Edition
PublisherElsevier Inc.
Pages299-311
Number of pages13
Volume1
ISBN (Print)9780123973399, 9780444594532
DOIs
StatePublished - Oct 28 2014

Fingerprint

Nervous System
Metals
Arsenic
Instinct
Digestive System
Bismuth
Endocrine System
Thallium
Peripheral Nervous System
Manganese
Selenium
Cardiovascular System
Neurologic Manifestations
Aluminum
Mercury
Cadmium
Lithium
Respiratory System
Cognition
Names

Keywords

  • Central nervous system
  • Neurobehavioral changes
  • Neurodegeneration
  • Neurotoxicity
  • Peripheral nervous system

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lucchini, R. G., Aschner, M., Bellinger, D. C., & Caito, S. W. (2014). Neurotoxicology of Metals. In Handbook on the Toxicology of Metals: Fourth Edition (Vol. 1, pp. 299-311). Elsevier Inc.. https://doi.org/10.1016/B978-0-444-59453-2.00015-9

Neurotoxicology of Metals. / Lucchini, Roberto G.; Aschner, Michael; Bellinger, David C.; Caito, Samuel W.

Handbook on the Toxicology of Metals: Fourth Edition. Vol. 1 Elsevier Inc., 2014. p. 299-311.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lucchini, RG, Aschner, M, Bellinger, DC & Caito, SW 2014, Neurotoxicology of Metals. in Handbook on the Toxicology of Metals: Fourth Edition. vol. 1, Elsevier Inc., pp. 299-311. https://doi.org/10.1016/B978-0-444-59453-2.00015-9
Lucchini RG, Aschner M, Bellinger DC, Caito SW. Neurotoxicology of Metals. In Handbook on the Toxicology of Metals: Fourth Edition. Vol. 1. Elsevier Inc. 2014. p. 299-311 https://doi.org/10.1016/B978-0-444-59453-2.00015-9
Lucchini, Roberto G. ; Aschner, Michael ; Bellinger, David C. ; Caito, Samuel W. / Neurotoxicology of Metals. Handbook on the Toxicology of Metals: Fourth Edition. Vol. 1 Elsevier Inc., 2014. pp. 299-311
@inbook{00870cd422fd465e83a3782592e7ec36,
title = "Neurotoxicology of Metals",
abstract = "The nervous system has many functions, including the coordination and regulation of homeostasis of the respiratory, digestive, circulatory, and endocrine systems, to name just a few. The nervous system also controls movement and sensory perception. In addition, innate behavior originates within the nervous system, as do higher cognitive functions, which define personality and enable learning, memory, and emotions. As a result, toxicants that affect the nervous system cause broad effects across many physiological and psychological domains. Several metals, such as aluminum (Al), arsenic (As), copper (Cu), lead (Pb), manganese (Mn), mercury (Hg) and thallium (Tl), are known to be neurotoxic to the central and peripheral nervous system. There is also some evidence of neurotoxicity for alkyltin (alkyl-Sn), bismuth (Bi), cadmium (Cd), lithium (Li), selenium (Se) and zinc (Zn). From clinical neurological manifestations occurring in occupational settings, attention is now focused on preclinical neurobehavioral effects in susceptible subpopulations such as pregnant women and children. Through their long-term deposition in the body, metals may also have a role in neurodegeneration.",
keywords = "Central nervous system, Neurobehavioral changes, Neurodegeneration, Neurotoxicity, Peripheral nervous system",
author = "Lucchini, {Roberto G.} and Michael Aschner and Bellinger, {David C.} and Caito, {Samuel W.}",
year = "2014",
month = "10",
day = "28",
doi = "10.1016/B978-0-444-59453-2.00015-9",
language = "English (US)",
isbn = "9780123973399",
volume = "1",
pages = "299--311",
booktitle = "Handbook on the Toxicology of Metals: Fourth Edition",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Neurotoxicology of Metals

AU - Lucchini, Roberto G.

AU - Aschner, Michael

AU - Bellinger, David C.

AU - Caito, Samuel W.

PY - 2014/10/28

Y1 - 2014/10/28

N2 - The nervous system has many functions, including the coordination and regulation of homeostasis of the respiratory, digestive, circulatory, and endocrine systems, to name just a few. The nervous system also controls movement and sensory perception. In addition, innate behavior originates within the nervous system, as do higher cognitive functions, which define personality and enable learning, memory, and emotions. As a result, toxicants that affect the nervous system cause broad effects across many physiological and psychological domains. Several metals, such as aluminum (Al), arsenic (As), copper (Cu), lead (Pb), manganese (Mn), mercury (Hg) and thallium (Tl), are known to be neurotoxic to the central and peripheral nervous system. There is also some evidence of neurotoxicity for alkyltin (alkyl-Sn), bismuth (Bi), cadmium (Cd), lithium (Li), selenium (Se) and zinc (Zn). From clinical neurological manifestations occurring in occupational settings, attention is now focused on preclinical neurobehavioral effects in susceptible subpopulations such as pregnant women and children. Through their long-term deposition in the body, metals may also have a role in neurodegeneration.

AB - The nervous system has many functions, including the coordination and regulation of homeostasis of the respiratory, digestive, circulatory, and endocrine systems, to name just a few. The nervous system also controls movement and sensory perception. In addition, innate behavior originates within the nervous system, as do higher cognitive functions, which define personality and enable learning, memory, and emotions. As a result, toxicants that affect the nervous system cause broad effects across many physiological and psychological domains. Several metals, such as aluminum (Al), arsenic (As), copper (Cu), lead (Pb), manganese (Mn), mercury (Hg) and thallium (Tl), are known to be neurotoxic to the central and peripheral nervous system. There is also some evidence of neurotoxicity for alkyltin (alkyl-Sn), bismuth (Bi), cadmium (Cd), lithium (Li), selenium (Se) and zinc (Zn). From clinical neurological manifestations occurring in occupational settings, attention is now focused on preclinical neurobehavioral effects in susceptible subpopulations such as pregnant women and children. Through their long-term deposition in the body, metals may also have a role in neurodegeneration.

KW - Central nervous system

KW - Neurobehavioral changes

KW - Neurodegeneration

KW - Neurotoxicity

KW - Peripheral nervous system

UR - http://www.scopus.com/inward/record.url?scp=84943532068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943532068&partnerID=8YFLogxK

U2 - 10.1016/B978-0-444-59453-2.00015-9

DO - 10.1016/B978-0-444-59453-2.00015-9

M3 - Chapter

SN - 9780123973399

SN - 9780444594532

VL - 1

SP - 299

EP - 311

BT - Handbook on the Toxicology of Metals: Fourth Edition

PB - Elsevier Inc.

ER -