Neurotoxicity of manganese: Indications for future research and public health intervention from the Manganese 2016 conference

Roberto G. Lucchini, Michael Aschner, Philip J. Landrigan, Joan M. Cranmer

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Manganese is an essential trace element, but also at high levels a neurotoxicant. Manganese neurotoxicity has been extensively studied since its discovery in highly exposed workers. The International conference MANGANESE2016 held at the Icahn School of Medicine at Mount Sinai in New York provided relevant updates on manganese research in relation to both occupational and environmental exposures. Epidemiological, toxicological and cellular studies reported at the conference have yielded new insights on mechanisms of manganese toxicity and on opportunities for preventive intervention. Strong evidence now exists for causal associations between manganese and both neurodevelopmental and neurodegenerative disorders. The neurodevelopmental effects of early life exposures are an example of the developmental origin of health and disease (DOHAD) concept. Brain imaging has rapidly become an important tool for examining brain areas impacted by manganese at various life stages. Candidate biomarkers of exposure are being identified in hair, nails, and teeth and reflect different exposure windows and relate to different health outcomes. Sex differences were reported in several studies, suggesting that women are more susceptible. New evidence indicates that the transporter genes SLC30A10 and SLC39A8 influence both manganese homeostasis and toxicity. New potential chelation modalities are being developed.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroToxicology
Volume64
DOIs
StatePublished - Jan 1 2018

Fingerprint

Public health
Manganese
Public Health
Toxicity
Brain
Health
Nails
Environmental Exposure
Trace Elements
Biomarkers
Occupational Exposure
Chelation
Neuroimaging
Sex Characteristics
Neurodegenerative Diseases
Hair
Toxicology
Medicine
Tooth
Homeostasis

Keywords

  • Brain imaging
  • Developmental origins of adult disease
  • Manganese
  • Neurodegenerative effects
  • Neurodevelopmental effects
  • Neurotoxicity
  • Occupational environmental exposure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

Cite this

Neurotoxicity of manganese : Indications for future research and public health intervention from the Manganese 2016 conference. / Lucchini, Roberto G.; Aschner, Michael; Landrigan, Philip J.; Cranmer, Joan M.

In: NeuroToxicology, Vol. 64, 01.01.2018, p. 1-4.

Research output: Contribution to journalArticle

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