Neurotoxic mechanisms of fish-borne methylmercury

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Methylmercury (MeHg) epidemics and studies in fish-eating populations have provided invaluable insights into the neurotoxic sequelae of MeHg exposure. MeHg is a ubiquitous environmental contaminant, and its accumulation in the food chain will continue to pose health risks given anthropogenic and natural contamination. This review briefly addresses recent epidemiological data associated with exposure to MeHg in fish-eating populations, identifies mechanisms of MeHg transport into the central nervous system (CNS), and discusses various theories on cellular processes afflicted by MeHg, which most certainly include astrocytic failure to maintain the composition of the extracellular fluid.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalEnvironmental Toxicology and Pharmacology
Volume12
Issue number2
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Keywords

  • Fish-transport
  • Metallothionein
  • Methylmercury
  • Neurotoxicity

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

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