Neuropsychological strategies for detecting early dementia

Ellen Groeber, Charles Hall, Maryannne McGinn, Toni Nicholls, Stephanie Stanford, Amy Ehrlich, Laurie G. Jacobs, Gary Kennedy, Amy Sanders, Richard B. Lipton

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

As new and more effective treatments for Alzheimer's disease (AD) emerge, the development of efficient screening strategies in educationally and racially diverse primary care settings has increased in importance. A set of candidate screening tests and an independent diagnostic assessment were administered to a sample of 318 patients treated at a geriatric primary care center. Fifty-six subjects met criteria for dementia. Exploratory analysis led to the development of three two-stage screening strategies that differed in the composition of the first stage or Rapid Dementia Screen, which is applied to all patients over the age of 65. The second stage, applied to those patients who screen positively for dementia, is accomplished with the Free and Cued Selective Reminding Test to detect memory impairment. Using clinical diagnosis as a gold standard, the strategies had high sensitivity and specificity for identifying dementia and performed better for identifying AD than non-AD dementias. Sensitivity and specificity did not differ by race or education. The strategies provide an efficient approach to screening for early dementia.

Original languageEnglish (US)
Pages (from-to)130-142
Number of pages13
JournalJournal of the International Neuropsychological Society
Volume14
Issue number1
DOIs
StatePublished - Jan 2008

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Keywords

  • African Americans
  • Alzheimer disease
  • Mass screening
  • Mild cognitive impairment
  • Neuropsychological tests
  • Primary health care

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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