Neuropsychological latent classes at enrollment and postmortem neuropathology

Andrea R. Zammit, Charles B. Hall, David A. Bennett, Ali Ezzati, Mindy Joy Katz, Graciela Muniz-Terrera, Richard B. Lipton

Research output: Contribution to journalArticle

Abstract

Introduction: We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator. Methods: Brain autopsies of 779 decedents were examined. Baseline latent class analysis on 10 neuropsychological measures was previously assigned: mixed-domains impairment (n = 39, 5%), memory-specific impairment (n = 210, 27%), frontal impairment (n = 113, 14.5%), average cognition (n = 360, 46.2%), and superior cognition (n = 57, 7.3%). Linear regressions and risks ratios were used to examine the relation of latent class assignment at enrollment with neuropathological indices. Results: Amyloid β, tau, and transactive response DNA-binding protein 43 were associated with mixed-domains impairment and memory-specific impairment classes ∼7 years before death. Moderate arteriolosclerosis was associated with membership in the frontal impairment class. Discussion: Our findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2019

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Cognition
Arteriolosclerosis
DNA-Binding Proteins
Amyloid
Autopsy
Linear Models
Odds Ratio
Brain
Neuropathology
Cognitive Dysfunction

Keywords

  • Alzheimer's dementia
  • Heterogeneity
  • Individual differences
  • Latent variable modeling
  • Neuropathology
  • Neuropsychology

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

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title = "Neuropsychological latent classes at enrollment and postmortem neuropathology",
abstract = "Introduction: We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator. Methods: Brain autopsies of 779 decedents were examined. Baseline latent class analysis on 10 neuropsychological measures was previously assigned: mixed-domains impairment (n = 39, 5{\%}), memory-specific impairment (n = 210, 27{\%}), frontal impairment (n = 113, 14.5{\%}), average cognition (n = 360, 46.2{\%}), and superior cognition (n = 57, 7.3{\%}). Linear regressions and risks ratios were used to examine the relation of latent class assignment at enrollment with neuropathological indices. Results: Amyloid β, tau, and transactive response DNA-binding protein 43 were associated with mixed-domains impairment and memory-specific impairment classes ∼7 years before death. Moderate arteriolosclerosis was associated with membership in the frontal impairment class. Discussion: Our findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment.",
keywords = "Alzheimer's dementia, Heterogeneity, Individual differences, Latent variable modeling, Neuropathology, Neuropsychology",
author = "Zammit, {Andrea R.} and Hall, {Charles B.} and Bennett, {David A.} and Ali Ezzati and Katz, {Mindy Joy} and Graciela Muniz-Terrera and Lipton, {Richard B.}",
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AU - Hall, Charles B.

AU - Bennett, David A.

AU - Ezzati, Ali

AU - Katz, Mindy Joy

AU - Muniz-Terrera, Graciela

AU - Lipton, Richard B.

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N2 - Introduction: We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator. Methods: Brain autopsies of 779 decedents were examined. Baseline latent class analysis on 10 neuropsychological measures was previously assigned: mixed-domains impairment (n = 39, 5%), memory-specific impairment (n = 210, 27%), frontal impairment (n = 113, 14.5%), average cognition (n = 360, 46.2%), and superior cognition (n = 57, 7.3%). Linear regressions and risks ratios were used to examine the relation of latent class assignment at enrollment with neuropathological indices. Results: Amyloid β, tau, and transactive response DNA-binding protein 43 were associated with mixed-domains impairment and memory-specific impairment classes ∼7 years before death. Moderate arteriolosclerosis was associated with membership in the frontal impairment class. Discussion: Our findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment.

AB - Introduction: We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator. Methods: Brain autopsies of 779 decedents were examined. Baseline latent class analysis on 10 neuropsychological measures was previously assigned: mixed-domains impairment (n = 39, 5%), memory-specific impairment (n = 210, 27%), frontal impairment (n = 113, 14.5%), average cognition (n = 360, 46.2%), and superior cognition (n = 57, 7.3%). Linear regressions and risks ratios were used to examine the relation of latent class assignment at enrollment with neuropathological indices. Results: Amyloid β, tau, and transactive response DNA-binding protein 43 were associated with mixed-domains impairment and memory-specific impairment classes ∼7 years before death. Moderate arteriolosclerosis was associated with membership in the frontal impairment class. Discussion: Our findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment.

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