Abstract
This study investigated the effects of blind lithium discontinuation and resumption on measures of cognition, creativity, and fine motor performance in 46 lithium-maintained euthymic outpatients. Scores on memory measures, tests of tapping speed, and associative productivity all improved significantly during the time off of lithium. In an effort to further explain these results, analyses were undertaken with six possible intervening variables: age, sex, lithium concentration in plasma, thyroid function, duration of lithium maintenance, and depressive symptoms. Significant group and interactive effects are reported and discussed. A multiple regression analysis suggested that lithium has a greater neuropsychologic effect in younger, less-depressed patients having higher lithium concentrations in plasma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 268-276 |
| Number of pages | 9 |
| Journal | Journal of Clinical Psychopharmacology |
| Volume | 13 |
| Issue number | 4 |
| State | Published - Jan 1 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)
Cite this
Neuropsychologic effects of lithium discontinuation. / Kocsis, James H.; Shaw, Eric D.; Stokes, Peter E.; Wilner, Philip; Elliot, Alan S.; Sikes, Carolyn; Myers, Barnett; Manevitz, Alan; Parides, Michael K.
In: Journal of Clinical Psychopharmacology, Vol. 13, No. 4, 01.01.1993, p. 268-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropsychologic effects of lithium discontinuation
AU - Kocsis, James H.
AU - Shaw, Eric D.
AU - Stokes, Peter E.
AU - Wilner, Philip
AU - Elliot, Alan S.
AU - Sikes, Carolyn
AU - Myers, Barnett
AU - Manevitz, Alan
AU - Parides, Michael K.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - This study investigated the effects of blind lithium discontinuation and resumption on measures of cognition, creativity, and fine motor performance in 46 lithium-maintained euthymic outpatients. Scores on memory measures, tests of tapping speed, and associative productivity all improved significantly during the time off of lithium. In an effort to further explain these results, analyses were undertaken with six possible intervening variables: age, sex, lithium concentration in plasma, thyroid function, duration of lithium maintenance, and depressive symptoms. Significant group and interactive effects are reported and discussed. A multiple regression analysis suggested that lithium has a greater neuropsychologic effect in younger, less-depressed patients having higher lithium concentrations in plasma.
AB - This study investigated the effects of blind lithium discontinuation and resumption on measures of cognition, creativity, and fine motor performance in 46 lithium-maintained euthymic outpatients. Scores on memory measures, tests of tapping speed, and associative productivity all improved significantly during the time off of lithium. In an effort to further explain these results, analyses were undertaken with six possible intervening variables: age, sex, lithium concentration in plasma, thyroid function, duration of lithium maintenance, and depressive symptoms. Significant group and interactive effects are reported and discussed. A multiple regression analysis suggested that lithium has a greater neuropsychologic effect in younger, less-depressed patients having higher lithium concentrations in plasma.
UR - http://www.scopus.com/inward/record.url?scp=0027181524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027181524&partnerID=8YFLogxK
M3 - Article
C2 - 8376614
AN - SCOPUS:0027181524
VL - 13
SP - 268
EP - 276
JO - Journal of Clinical Psychopharmacology
JF - Journal of Clinical Psychopharmacology
SN - 0271-0749
IS - 4
ER -