Neuropsychologic effects of lithium discontinuation

James H. Kocsis, Eric D. Shaw, Peter E. Stokes, Philip Wilner, Alan S. Elliot, Carolyn Sikes, Barnett Myers, Alan Manevitz, Michael K. Parides

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

This study investigated the effects of blind lithium discontinuation and resumption on measures of cognition, creativity, and fine motor performance in 46 lithium-maintained euthymic outpatients. Scores on memory measures, tests of tapping speed, and associative productivity all improved significantly during the time off of lithium. In an effort to further explain these results, analyses were undertaken with six possible intervening variables: age, sex, lithium concentration in plasma, thyroid function, duration of lithium maintenance, and depressive symptoms. Significant group and interactive effects are reported and discussed. A multiple regression analysis suggested that lithium has a greater neuropsychologic effect in younger, less-depressed patients having higher lithium concentrations in plasma.

Original languageEnglish (US)
Pages (from-to)268-276
Number of pages9
JournalJournal of Clinical Psychopharmacology
Volume13
Issue number4
StatePublished - Jan 1 1993
Externally publishedYes

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Lithium
Creativity
Cognition
Thyroid Gland
Outpatients
Regression Analysis
Maintenance
Depression
Efficiency

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kocsis, J. H., Shaw, E. D., Stokes, P. E., Wilner, P., Elliot, A. S., Sikes, C., ... Parides, M. K. (1993). Neuropsychologic effects of lithium discontinuation. Journal of Clinical Psychopharmacology, 13(4), 268-276.

Neuropsychologic effects of lithium discontinuation. / Kocsis, James H.; Shaw, Eric D.; Stokes, Peter E.; Wilner, Philip; Elliot, Alan S.; Sikes, Carolyn; Myers, Barnett; Manevitz, Alan; Parides, Michael K.

In: Journal of Clinical Psychopharmacology, Vol. 13, No. 4, 01.01.1993, p. 268-276.

Research output: Contribution to journalArticle

Kocsis, JH, Shaw, ED, Stokes, PE, Wilner, P, Elliot, AS, Sikes, C, Myers, B, Manevitz, A & Parides, MK 1993, 'Neuropsychologic effects of lithium discontinuation', Journal of Clinical Psychopharmacology, vol. 13, no. 4, pp. 268-276.
Kocsis JH, Shaw ED, Stokes PE, Wilner P, Elliot AS, Sikes C et al. Neuropsychologic effects of lithium discontinuation. Journal of Clinical Psychopharmacology. 1993 Jan 1;13(4):268-276.
Kocsis, James H. ; Shaw, Eric D. ; Stokes, Peter E. ; Wilner, Philip ; Elliot, Alan S. ; Sikes, Carolyn ; Myers, Barnett ; Manevitz, Alan ; Parides, Michael K. / Neuropsychologic effects of lithium discontinuation. In: Journal of Clinical Psychopharmacology. 1993 ; Vol. 13, No. 4. pp. 268-276.
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