Neuropsychiatric impairment in impulsive personality disorders

Dan J. Stein, Eric Hollander, Lisa Cohen, Maxim Frenkel, Jihad B. Saoud, Concetta DeCaria, Bonnie Aronowitz, Andrew Levin, Michael R. Liebowitz, Lee Cohen

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

It has been suggested that impulsivity and aggression are associated with neuropsychiatric impairment. Neurological soft signs may be a useful marker of nonspecific brain damage, and may therefore be increased in impulsive and aggressive patients compared with normal control subjects. A structured examination was used to evaluate neurological soft signs in 28 patients with personality disorders characterized by impulsivity and 28 healthy control subjects. All of the patients met DSM-III-R criteria for borderline personality disorder, and 10 also met criteria for antisocial personality disorder. All patients were questioned about past history of physical aggression, and a subset of 18 patients underwent neuropsychological testing with a select battery. Left-sided neurological soft signs were significantly increased in patients compared with normal control subjects. Patients with a history of aggression, however, had significantly more right-sided neurological soft signs than those without a history of aggression. Increased neurological soft signs were associated with impairment on the Wisconsin Card Sort, a test of frontal lobe executive function. Specific neuropsychiatric abnormalities, such as lateralized neurological soft signs and associated impairment on select neuropsychological tests, may be present in patients with personality disorders characterized by impulsivity.

Original languageEnglish (US)
Pages (from-to)257-266
Number of pages10
JournalPsychiatry Research
Volume48
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Personality Disorders
Aggression
Impulsive Behavior
Antisocial Personality Disorder
Borderline Personality Disorder
Neuropsychological Tests
Executive Function
Frontal Lobe
Diagnostic and Statistical Manual of Mental Disorders
Healthy Volunteers
Brain

Keywords

  • antisocial personality
  • borderline personality
  • cognition
  • Neurological soft signs
  • neuropsychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Stein, D. J., Hollander, E., Cohen, L., Frenkel, M., Saoud, J. B., DeCaria, C., ... Cohen, L. (1993). Neuropsychiatric impairment in impulsive personality disorders. Psychiatry Research, 48(3), 257-266. https://doi.org/10.1016/0165-1781(93)90076-S

Neuropsychiatric impairment in impulsive personality disorders. / Stein, Dan J.; Hollander, Eric; Cohen, Lisa; Frenkel, Maxim; Saoud, Jihad B.; DeCaria, Concetta; Aronowitz, Bonnie; Levin, Andrew; Liebowitz, Michael R.; Cohen, Lee.

In: Psychiatry Research, Vol. 48, No. 3, 1993, p. 257-266.

Research output: Contribution to journalArticle

Stein, DJ, Hollander, E, Cohen, L, Frenkel, M, Saoud, JB, DeCaria, C, Aronowitz, B, Levin, A, Liebowitz, MR & Cohen, L 1993, 'Neuropsychiatric impairment in impulsive personality disorders', Psychiatry Research, vol. 48, no. 3, pp. 257-266. https://doi.org/10.1016/0165-1781(93)90076-S
Stein, Dan J. ; Hollander, Eric ; Cohen, Lisa ; Frenkel, Maxim ; Saoud, Jihad B. ; DeCaria, Concetta ; Aronowitz, Bonnie ; Levin, Andrew ; Liebowitz, Michael R. ; Cohen, Lee. / Neuropsychiatric impairment in impulsive personality disorders. In: Psychiatry Research. 1993 ; Vol. 48, No. 3. pp. 257-266.
@article{c20a6e6340c74452b28391c3e4b50244,
title = "Neuropsychiatric impairment in impulsive personality disorders",
abstract = "It has been suggested that impulsivity and aggression are associated with neuropsychiatric impairment. Neurological soft signs may be a useful marker of nonspecific brain damage, and may therefore be increased in impulsive and aggressive patients compared with normal control subjects. A structured examination was used to evaluate neurological soft signs in 28 patients with personality disorders characterized by impulsivity and 28 healthy control subjects. All of the patients met DSM-III-R criteria for borderline personality disorder, and 10 also met criteria for antisocial personality disorder. All patients were questioned about past history of physical aggression, and a subset of 18 patients underwent neuropsychological testing with a select battery. Left-sided neurological soft signs were significantly increased in patients compared with normal control subjects. Patients with a history of aggression, however, had significantly more right-sided neurological soft signs than those without a history of aggression. Increased neurological soft signs were associated with impairment on the Wisconsin Card Sort, a test of frontal lobe executive function. Specific neuropsychiatric abnormalities, such as lateralized neurological soft signs and associated impairment on select neuropsychological tests, may be present in patients with personality disorders characterized by impulsivity.",
keywords = "antisocial personality, borderline personality, cognition, Neurological soft signs, neuropsychology",
author = "Stein, {Dan J.} and Eric Hollander and Lisa Cohen and Maxim Frenkel and Saoud, {Jihad B.} and Concetta DeCaria and Bonnie Aronowitz and Andrew Levin and Liebowitz, {Michael R.} and Lee Cohen",
year = "1993",
doi = "10.1016/0165-1781(93)90076-S",
language = "English (US)",
volume = "48",
pages = "257--266",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Neuropsychiatric impairment in impulsive personality disorders

AU - Stein, Dan J.

AU - Hollander, Eric

AU - Cohen, Lisa

AU - Frenkel, Maxim

AU - Saoud, Jihad B.

AU - DeCaria, Concetta

AU - Aronowitz, Bonnie

AU - Levin, Andrew

AU - Liebowitz, Michael R.

AU - Cohen, Lee

PY - 1993

Y1 - 1993

N2 - It has been suggested that impulsivity and aggression are associated with neuropsychiatric impairment. Neurological soft signs may be a useful marker of nonspecific brain damage, and may therefore be increased in impulsive and aggressive patients compared with normal control subjects. A structured examination was used to evaluate neurological soft signs in 28 patients with personality disorders characterized by impulsivity and 28 healthy control subjects. All of the patients met DSM-III-R criteria for borderline personality disorder, and 10 also met criteria for antisocial personality disorder. All patients were questioned about past history of physical aggression, and a subset of 18 patients underwent neuropsychological testing with a select battery. Left-sided neurological soft signs were significantly increased in patients compared with normal control subjects. Patients with a history of aggression, however, had significantly more right-sided neurological soft signs than those without a history of aggression. Increased neurological soft signs were associated with impairment on the Wisconsin Card Sort, a test of frontal lobe executive function. Specific neuropsychiatric abnormalities, such as lateralized neurological soft signs and associated impairment on select neuropsychological tests, may be present in patients with personality disorders characterized by impulsivity.

AB - It has been suggested that impulsivity and aggression are associated with neuropsychiatric impairment. Neurological soft signs may be a useful marker of nonspecific brain damage, and may therefore be increased in impulsive and aggressive patients compared with normal control subjects. A structured examination was used to evaluate neurological soft signs in 28 patients with personality disorders characterized by impulsivity and 28 healthy control subjects. All of the patients met DSM-III-R criteria for borderline personality disorder, and 10 also met criteria for antisocial personality disorder. All patients were questioned about past history of physical aggression, and a subset of 18 patients underwent neuropsychological testing with a select battery. Left-sided neurological soft signs were significantly increased in patients compared with normal control subjects. Patients with a history of aggression, however, had significantly more right-sided neurological soft signs than those without a history of aggression. Increased neurological soft signs were associated with impairment on the Wisconsin Card Sort, a test of frontal lobe executive function. Specific neuropsychiatric abnormalities, such as lateralized neurological soft signs and associated impairment on select neuropsychological tests, may be present in patients with personality disorders characterized by impulsivity.

KW - antisocial personality

KW - borderline personality

KW - cognition

KW - Neurological soft signs

KW - neuropsychology

UR - http://www.scopus.com/inward/record.url?scp=0027494409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027494409&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(93)90076-S

DO - 10.1016/0165-1781(93)90076-S

M3 - Article

VL - 48

SP - 257

EP - 266

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -